Ethnicity is an independent determinant of age-specific PSA level: Findings from a multiethnic Asian setting

Lim, Jasmine, Bhoo-Pathy, Nirmala, Sothilingam, Selvalingam, Malek, Rohan, Sundram, Murali, Bahadzor, Badrul Hisham, Ong, Teng Aik, Ng, Keng Lim, Sivalingam, Sivaprakasam and Razack, Azad Hassan Abdul (2014) Ethnicity is an independent determinant of age-specific PSA level: Findings from a multiethnic Asian setting. PLoS One, 9 8: e104917.1-e104917.7. doi:10.1371/journal.pone.0104917

Author Lim, Jasmine
Bhoo-Pathy, Nirmala
Sothilingam, Selvalingam
Malek, Rohan
Sundram, Murali
Bahadzor, Badrul Hisham
Ong, Teng Aik
Ng, Keng Lim
Sivalingam, Sivaprakasam
Razack, Azad Hassan Abdul
Title Ethnicity is an independent determinant of age-specific PSA level: Findings from a multiethnic Asian setting
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-08-11
Sub-type Article (original research)
DOI 10.1371/journal.pone.0104917
Open Access Status DOI
Volume 9
Issue 8
Start page e104917.1
End page e104917.7
Total pages 7
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract Objectives: To study the baseline PSA profile and determine the factors influencing the PSA levels within a multiethnic Asian setting. Materials and Methods: We conducted a cross-sectional study of 1054 men with no clinical evidence of prostate cancer, prostate surgery or 5α-reductase inhibitor treatment of known prostate conditions. The serum PSA concentration of each subject was assayed. Potential factors associated with PSA level including age, ethnicity, height, weight, family history of prostate cancer, lower urinary tract voiding symptoms (LUTS), prostate volume and digital rectal examination (DRE) were evaluated using univariable and multivariable analysis. Results: There were 38 men (3.6%) found to have a PSA level above 4 ng/ml and 1016 (96.4%) with a healthy PSA (≤4 ng/ml). The median PSA level of Malay, Chinese and Indian men was 1.00 ng/ml, 1.16 ng/ml and 0.83 ng/ml, respectively. Indians had a relatively lower median PSA level and prostate volume than Malays and Chinese, who shared a comparable median PSA value across all 10-years age groups. The PSA density was fairly similar amongst all ethnicities. Further analysis showed that ethnicity, weight and prostate volume were independent factors associated with age specific PSA level in the multivariable analysis (p<0.05). Conclusion: These findings support the concept that the baseline PSA level varies between different ethnicities across all age groups. In addition to age and prostate volume, ethnicity may also need to be taken into account when investigating serum PSA concentrations in the multiethnic Asian population.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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