Bmp signaling exerts opposite effects on cardiac differentiation

de Pater, Emma, Ciampricotti, Metamia, Priller, Florian, Veerkamp, Justus, Strate, Ina, Smith, Kelly, Lagendijk, Anne Karine, Schilling, Thomas F., Herzog, Wiebke, Abdelilah-Seyfried, Salim, Hammerschmidt, Matthias and Bakkers, Jeroen (2012) Bmp signaling exerts opposite effects on cardiac differentiation. Circulation Research, 110 4: 578-587. doi:10.1161/CIRCRESAHA.111.261172

Author de Pater, Emma
Ciampricotti, Metamia
Priller, Florian
Veerkamp, Justus
Strate, Ina
Smith, Kelly
Lagendijk, Anne Karine
Schilling, Thomas F.
Herzog, Wiebke
Abdelilah-Seyfried, Salim
Hammerschmidt, Matthias
Bakkers, Jeroen
Title Bmp signaling exerts opposite effects on cardiac differentiation
Journal name Circulation Research   Check publisher's open access policy
ISSN 0009-7330
Publication date 2012-02-17
Sub-type Article (original research)
DOI 10.1161/CIRCRESAHA.111.261172
Open Access Status Not Open Access
Volume 110
Issue 4
Start page 578
End page 587
Total pages 10
Place of publication Baltimore, MD, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Rationale: The importance for Bmp signaling during embryonic stem cell differentiation into myocardial cells has been recognized. The question when and where Bmp signaling in vivo regulates myocardial differentiation has remained largely unanswered.

Objective: To identify when and where Bmp signaling regulates cardiogenic differentiation.

Methods and Results: Here we have observed that in zebrafish embryos, Bmp signaling is active in cardiac progenitor cells prior to their differentiation into cardiomyocytes. Bmp signaling is continuously required during somitogenesis within the anterior lateral plate mesoderm to induce myocardial differentiation. Surprisingly, Bmp signaling is actively repressed in differentiating myocardial cells. We identified the inhibitory Smad6a, which is expressed in the cardiac tissue, to be required to inhibit Bmp signaling and thereby promote expansion of the ventricular myocardium.

Conclusions: Bmp signaling exerts opposing effects on myocardial differentiation in the embryo by promoting as well as inhibiting cardiac growth. 
Keyword BMP
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
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