Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Catts, Stanley V., Gratten, Jacob, Lee, S. Hong, Wray, Naomi R., Visscher, Peter M., Mowry, Bryan J., Nertney, Deborah A., Psychosis Endophenotypes International Consortium and Wellcome Trust Case-Control Consortium 2 (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511 7510: 421-427. doi:10.1038/nature13595

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ336929_OA.pdf Full text (open access) application/pdf 1.37MB 0

Author Schizophrenia Working Group of the Psychiatric Genomics Consortium
Catts, Stanley V.
Gratten, Jacob
Lee, S. Hong
Wray, Naomi R.
Visscher, Peter M.
Mowry, Bryan J.
Nertney, Deborah A.
Psychosis Endophenotypes International Consortium
Wellcome Trust Case-Control Consortium 2
Title Biological insights from 108 schizophrenia-associated genetic loci
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 2014-01-01
Sub-type Article (original research)
DOI 10.1038/nature13595
Open Access Status File (Author Post-print)
Volume 511
Issue 7510
Start page 421
End page 427
Total pages 7
Place of publication London, Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 699 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1477 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 12 Aug 2014, 13:22:42 EST by System User on behalf of Medicine - Royal Brisbane and Women's Hospital