The significance of oral and systemic factors in Australian and Croatian patients with oral lichen planus

Boras, Vanja Vucicevic, Savage, Neil William, Brailo, Vlaho, Skrinjar, Ivana, Valter, Kruna, Alajbeg, Iva, Dulcic, Niksa and Juras, Danica Vidovic (2014) The significance of oral and systemic factors in Australian and Croatian patients with oral lichen planus. Acta Dermatovenerologica Croatica, 22 2: 97-102.

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Name Description MIMEType Size Downloads
Author Boras, Vanja Vucicevic
Savage, Neil William
Brailo, Vlaho
Skrinjar, Ivana
Valter, Kruna
Alajbeg, Iva
Dulcic, Niksa
Juras, Danica Vidovic
Title The significance of oral and systemic factors in Australian and Croatian patients with oral lichen planus
Journal name Acta Dermatovenerologica Croatica   Check publisher's open access policy
ISSN 1330-027X
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
Volume 22
Issue 2
Start page 97
End page 102
Total pages 6
Place of publication Zagreb University Hospital Center, Zagreb, Croatia
Publisher Croatian Dermatovenerological Society
Language eng
Subject 2708 Dermatology
2725 Infectious Diseases
Formatted abstract
Oral lichen planus (OLP) is an immunologically T cell-mediated disease caused by an unknown stimulus. Despite intensive investigation its pathogenesis still remains unknown. A few possible associations between OLP and certain diseases such as thyroid and malignant diseases as well as specific medication intake have been proposed in the literature with inconsistent findings.
We aimed to investigate the profile of 163 Australian and 163 Croatian OLP patients with special regard to their systemic diseases, medication intake (with special regard to the drugs that metabolize through Cytochrome P450), OLP type and localization, as well as involvement of other body surfaces with lichen. We did not find any statistical significance with regard to the OLP presence and thyroid and malignant diseases. As expected, the reticular type of OLP was most prevalent, as well as involvement of the both buccal mucosas. There was no significant association with other oral diseases such as labial herpes. Simultaneous involvement of other body surfaces in patients with OLP does not seem to be prevalent. None of the
medical conditions which were investigated had significant correlation with OLP neither in Australian nor in Croatian patients with OLP. Furthermore, the use of drugs which metabolize through Cytochrome P450 (CYP450) was not significantly correlated with OLP in either studied population. Therefore, we conclude that patients with OLP are not to be routinely screened for any systemic conditions.
Keyword Australia
Oral lichen planus
Systemic diseases
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Dentistry Publications
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