A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial

Gray, Darren J., Li, Yue-Sheng, Williams, Gail M., Zhao, Zheng-Yuan, Harn, Donald A., Li, Sheng-Ming, Ren, Mao-Yuan, Feng, Zeng, Guo, Feng-Ying, Guo, Jia-Gang, Zhou, Jie, Dong, Yu-Lan, Li, Yuan, Ross, Allen G. and McManus, Donald P. (2014) A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial. International Journal for Parasitology, 44 9: 659-668. doi:10.1016/j.ijpara.2014.05.005


Author Gray, Darren J.
Li, Yue-Sheng
Williams, Gail M.
Zhao, Zheng-Yuan
Harn, Donald A.
Li, Sheng-Ming
Ren, Mao-Yuan
Feng, Zeng
Guo, Feng-Ying
Guo, Jia-Gang
Zhou, Jie
Dong, Yu-Lan
Li, Yuan
Ross, Allen G.
McManus, Donald P.
Title A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial
Journal name International Journal for Parasitology   Check publisher's open access policy
ISSN 0020-7519
1879-0135
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.ijpara.2014.05.005
Volume 44
Issue 9
Start page 659
End page 668
Total pages 10
Place of publication London, United Kingdom
Publisher Elsevier Ltd
Collection year 2015
Language eng
Subject 2405 Parasitology
2725 Infectious Diseases
Abstract Despite major successes in its control over the past 50. years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result in new habitats for the oncomelanid intermediate snail host of Schistosoma japonicum (Sj), thereby increasing the risk of transmission. The current national control program for P.R. China involves a multi-component integrated strategy but, despite targeting multiple transmission pathways, certain challenges remain. As the Chinese government pushes towards elimination, there is a requirement for additional tools, such as vaccination, for long-term prevention. Whereas the zoonotic nature of schistosomiasis japonica adds to the complexity of control, it provides a unique opportunity to develop a transmission blocking vaccine targeting bovines to assist in the prevention of human infection and disease. Mathematical modelling has shown that control options targeting the various transmission pathways of schistosomiasis japonica and incorporating bovine vaccination, mass human chemotherapy and mollusciciding could lead to its elimination from P.R. China. Here we present the study design and baseline results of a four-year cluster randomised intervention trial we are undertaking around the schistosomiasis-endemic Dongting Lake in Hunan Province aimed at determining the impact on schistosome transmission of the multi-component integrated control strategy, including bovine vaccination using a heterologous "prime-boost" delivery platform based on the previously tested SjCTPI vaccine.
Keyword China
Integrated control
Dongting Lake
Schistosoma japonicum
Schistosomiasis
Schistosomiasis japonica
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 12 Aug 2014, 12:14:34 EST by System User on behalf of School of Public Health