Molecular classification of breast cancer

Vuong, Darina, Simpson, Peter T., Green, Benjamin, Cummings, Margaret C. and Lakhani, Sunil R. (2014) Molecular classification of breast cancer. Virchows Archiv, 465 1: 1-14. doi:10.1007/s00428-014-1593-7

Author Vuong, Darina
Simpson, Peter T.
Green, Benjamin
Cummings, Margaret C.
Lakhani, Sunil R.
Title Molecular classification of breast cancer
Journal name Virchows Archiv   Check publisher's open access policy
ISSN 1432-2307
Publication date 2014-07-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00428-014-1593-7
Open Access Status Not yet assessed
Volume 465
Issue 1
Start page 1
End page 14
Total pages 14
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Subject 2734 Pathology and Forensic Medicine
1307 Cell Biology
1312 Molecular Biology
Abstract Breast cancer is a complex, multifaceted disease encompassing a great variety of entities that show considerable variation in clinical, morphological and molecular attributes. Traditional classifications including histological assessment and clinical staging are used to guide patient management. In recent years, there has been exponential progress in molecular analysis with profound implications for our understanding of breast cancer biology and, hence, classification. There are now genome-based frameworks for the molecular categorisation of breast cancer including the development of prognostic and predictive signatures that potentially allow individualisation of treatment. Here we review the current state of the molecular classifications of in situ and invasive breast cancer including special subtypes. Future perspectives are also provided.
Keyword Biomarkers
Breast cancer molecular pathology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
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