Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Da Cunha, Violette, Davies, Mark R., Douarre, Pierre-Emmanuel, Rosinski-Chupin, Isabelle, Margarit, Immaculada, Spinali, Sebastien, Perkins, Tim, Lechat, Pierre, Dmytruk, Nicolas, Sauvage, Elisabeth, Ma, Laurence, Romi, Benedetta, Tichit, Magali, Lopez-Sanchez, Maria-Jose, Descorps-Declere, Stephane, Souche, Erika, Buchrieser, Carmen, Trieu-Cuot, Patrick, Moszer, Ivan, Clermont, Dominique, Maione, Domenico, Bouchier, Christiane, McMillan, David J., Parkhill, Julian, Telford, John L., Dougan, Gordan, Walker, Mark J., The DEVANI Consortium, Holden, Matthew T. G., Poyart, Claire and Glaser, Philippe (2014) Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 5 4544.1-4544.11. doi:10.1038/ncomms5544


 
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Author Da Cunha, Violette
Davies, Mark R.
Douarre, Pierre-Emmanuel
Rosinski-Chupin, Isabelle
Margarit, Immaculada
Spinali, Sebastien
Perkins, Tim
Lechat, Pierre
Dmytruk, Nicolas
Sauvage, Elisabeth
Ma, Laurence
Romi, Benedetta
Tichit, Magali
Lopez-Sanchez, Maria-Jose
Descorps-Declere, Stephane
Souche, Erika
Buchrieser, Carmen
Trieu-Cuot, Patrick
Moszer, Ivan
Clermont, Dominique
Maione, Domenico
Bouchier, Christiane
McMillan, David J.
Parkhill, Julian
Telford, John L.
Dougan, Gordan
Walker, Mark J.
The DEVANI Consortium
Holden, Matthew T. G.
Poyart, Claire
Glaser, Philippe
Total Author Count Override 31
Title Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Formatted title
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2014-08-01
Sub-type Article (original research)
DOI 10.1038/ncomms5544
Open Access Status DOI
Volume 5
Start page 4544.1
End page 4544.11
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Formatted abstract
Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 39 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 08 Aug 2014, 22:03:01 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences