Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula

Schmidt, Ewoud Roberto Eduard, Brignani, Sara, Adolfs, Youri, Lemstra, Suzanne, Demmers, Jeroen, Vidaki, Marina, Donahoo, Amber-Lee Skye, Lillevali, Kersti, Vasar, Eero, Richards, Linda Jane, Karagogeos, Domna, Kolk, Sharon Margriet and Pasterkamp, Ronald Jeroen (2014) Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. Neuron, 83 2: 372-387. doi:10.1016/j.neuron.2014.05.036

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Author Schmidt, Ewoud Roberto Eduard
Brignani, Sara
Adolfs, Youri
Lemstra, Suzanne
Demmers, Jeroen
Vidaki, Marina
Donahoo, Amber-Lee Skye
Lillevali, Kersti
Vasar, Eero
Richards, Linda Jane
Karagogeos, Domna
Kolk, Sharon Margriet
Pasterkamp, Ronald Jeroen
Title Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula
Journal name Neuron   Check publisher's open access policy
ISSN 1097-4199
0896-6273
Publication date 2014-07-16
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.neuron.2014.05.036
Open Access Status File (Author Post-print)
Volume 83
Issue 2
Start page 372
End page 387
Total pages 16
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Subject 2800 Neuroscience
Abstract A dominant feature of neural circuitry is the organization of neuronal projections and synapses into specific brain nuclei or laminae. Lamina-specific connectivity is controlled by the selective expression of extracellular guidance and adhesion molecules in the target field. However, how (sub)nucleus-specific connections are established and whether axon-derived cues contribute to subdomain targeting are largely unknown. Here, we demonstrate that the lateral subnucleus of the habenula (lHb) determines its own afferent innervation by sending out efferent projections that express the cell adhesion molecule LAMP to reciprocally collect and guide dopaminergic afferents to the lHb-a phenomenon we term subdomain-mediated axon-axon signaling. This process of reciprocal axon-axon interactions cooperates with lHb-specific chemoattraction mediated by Netrin-1, which controls axon target entry, to ensure specific innervation of the lHb. We propose that cooperation between pretarget reciprocal axon-axon signaling and subdomain-restricted instructive cues provides a highly precise and general mechanism to establish subdomain-specific neural circuitry.
Keyword General Neuroscience
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 222999
289581
T5-207
631466
IUT20-41
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
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