Is statin use associated with new joint-related symptoms, physical function and quality of life? The Australian Longitudinal Study on Women’s Health

Peeters, Geeske, Tett, Susan E., Conaghan, Philip G., Mishra, Gita D. and Dobson, Annette J. (2015) Is statin use associated with new joint-related symptoms, physical function and quality of life? The Australian Longitudinal Study on Women’s Health. Arthritis Care and Research, 67 1: 13-20. doi:10.1002/acr.22389


Author Peeters, Geeske
Tett, Susan E.
Conaghan, Philip G.
Mishra, Gita D.
Dobson, Annette J.
Title Is statin use associated with new joint-related symptoms, physical function and quality of life? The Australian Longitudinal Study on Women’s Health
Journal name Arthritis Care and Research   Check publisher's open access policy
ISSN 2151-464X
2151-4658
Publication date 2015-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1002/acr.22389
Open Access Status Not Open Access
Volume 67
Issue 1
Start page 13
End page 20
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 2745 Rheumatology
Abstract Previous studies have suggested that statins may prevent development of osteoarthritis and have antiinflammatory effects. Our aim was to examine the associations between statin use and patient-reported joint symptoms in 2 large cohorts of middle-aged and older women.
Formatted abstract
Objectives: Previous studies have suggested that statins may prevent development of osteoarthritis and have anti-inflammatory effects. Our aim was to examine the associations between statin use and patient-reported joint symptoms in two large cohorts of middle-aged and older women.

Methods: Data were from 6966 mid-age (born 1946-51) and 4806 older (born 1921-26) participants in the Australian Longitudinal Study on Women’s Health who completed surveys from 2001 to 2011 including questions about joint pain/stiffness, physical functioning and self-rated health (SRH). Administrative pharmaceutical data were used to classify participants according to statin use, cumulative volume of statin use and type of drug. Associations between statin use and newly reported symptoms were analysed using logistic regression with generalized estimating equations to account for repeated measures.

Results: 2096 (31.3%) of the mid-age women and 2473 (51.5%) of the older women were classified as statin users. After adjustment for confounders, statin use in mid-age women was weakly associated with poor physical functioning (odds ratio [OR]=1.29, 99% confidence interval [CI]=1.07-1.55) and poor SRH (OR=1.35, CI=1.13-1.61), but not with new joint pain/stiffness (OR=1.09, CI=0.88-1.34). No dose-response relationships were found. Pravastatin and atorvastatin were associated with poor physical functioning, while atorvastatin was also associated with poor SRH. Associations found in older women were mostly explained by confounders.

Conclusions: This large study did not demonstrate an association between statin use and reduced onset of joint pain/stiffness. Associations between statin use and poor physical functioning and poor self-rated health may be explained by factors other than joint pain/stiffness, for example muscle pain.
Keyword Rheumatology
Rheumatology
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID MR/L01629X/1
Institutional Status UQ

 
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Created: Tue, 05 Aug 2014, 02:17:45 EST by Dr Geeske Peeters on behalf of School of Public Health