Insight into hyaluronic acid molecular weight control

Marcellin, Esteban, Steen, Jennifer A. and Nielsen, Lars K. (2014) Insight into hyaluronic acid molecular weight control. Applied Microbiology and Biotechnology, 98 16: 6947-6956. doi:10.1007/s00253-014-5853-x


Author Marcellin, Esteban
Steen, Jennifer A.
Nielsen, Lars K.
Title Insight into hyaluronic acid molecular weight control
Journal name Applied Microbiology and Biotechnology   Check publisher's open access policy
ISSN 0175-7598
1432-0614
Publication date 2014-08-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00253-014-5853-x
Open Access Status Not yet assessed
Volume 98
Issue 16
Start page 6947
End page 6956
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract Hyaluronic acid (HA) is a ubiquitous polysaccharide found in humans, animals, bacteria, algae and molluscs. Simple yet sophisticated, HA demonstrates unique and valuable rheological properties. In solution, HA behaves as a stiffened random coil and the resultant behaviour, even at low concentrations, is far from Newtonian or ‘ideal’. These rheological properties are heavily influenced by molecular weight (MW), so it is not surprising that many of the biological functions of HA are dependent on molecular size. The current billion dollar market for HA continues to grow rapidly, both in gross production and the number of applications for its use. Increasing demand, in conjunction with a reticence to use animal-derived HA, has revitalised the market for HA produced by bacterial fermentation. Although the genes and pathways involved in bacterial production of HA are well characterised, the mechanisms that underlie HA MW control are less well understood. By performing a thorough analysis of the proposed mechanisms of MW control in bacterial fermentation, this mini-review tries to elucidate the challenges and future directions for bacterial HA biosynthesis.
Keyword Hyaluronicacid
Molecular weightcontrol
Polysaccharides
Streptococcus zooepidemicus
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01 CA173292
T32 GM08545
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 01 Aug 2014, 01:22:46 EST by Mr Esteban Marcellin Saldana on behalf of Aust Institute for Bioengineering & Nanotechnology