High flow nasal cannula therapy for respiratory support in children (Review)

Mayfield, Sara, Jauncey-Cooke, Jacqueline, Hough, Judith L., Schibler, Andreas and Bogossian, Fiona (2014) High flow nasal cannula therapy for respiratory support in children (Review). Cochrane Database of Systematic Reviews, 2014 3: CD009850.pub2.1-CD009850.pub2.31. doi:10.1002/14651858.CD009850.pub2

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Author Mayfield, Sara
Jauncey-Cooke, Jacqueline
Hough, Judith L.
Schibler, Andreas
Bogossian, Fiona
Title High flow nasal cannula therapy for respiratory support in children (Review)
Journal name Cochrane Database of Systematic Reviews   Check publisher's open access policy
ISSN 1469-493X
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1002/14651858.CD009850.pub2
Open Access Status File (Publisher version)
Volume 2014
Issue 3
Start page CD009850.pub2.1
End page CD009850.pub2.31
Total pages 32
Place of publication Oxford, United Kingdom
Publisher John Wiley and Sons Ltd.
Language eng
Formatted abstract
We reviewed evidence on the effectiveness of high-flow nasal cannula (HFNC) therapy in supporting children's breathing. We found 11 studies in children.


HFNC therapy delivers a mixture of air and oxygen via tubing that sits just inside the nostrils. For children hospitalized with breathing difficulties caused by conditions such as pneumonia or trauma or after surgery, HFNC therapy may help to support their breathing. This may reduce the need for other forms of breathing support such as life support. HFNC therapy can be used within the hospital ward setting, the emergency department or the intensive care unit. This Cochrane review is important because it assesses available evidence on the safety and effectiveness of HFNC compared with other forms of respiratory support, to help inform clinicians caring for children with breathing difficulties.

Search date

We searched medical databases from the 1950s until April 2013.

Study characteristics

We included studies on children from four weeks to 16 years of age. We searched for randomized controlled trials; however we excluded studies involving infants with bronchiolitis (a respiratory illness affecting infants that typically mimics a common cold) because children with this condition are included in another Cochrane review.


We found 11 studies involving children; however none matched our criteria.


It is important that good-quality studies are completed to identify indications as to the use and effectiveness of HFNC therapy in supporting the breathing of ill children.
Keyword Medicine, General & Internal
General & Internal Medicine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Nursing, Midwifery and Social Work Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 29 Jul 2014, 23:39:14 EST by Amy Spence on behalf of School of Nursing, Midwifery and Social Work