A phase-specific neuroimmune model of clinical depression

Eyre, H. A., Stuart, M. J. and Baune, B. T. (2014) A phase-specific neuroimmune model of clinical depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 54 265-274. doi:10.1016/j.pnpbp.2014.06.011


Author Eyre, H. A.
Stuart, M. J.
Baune, B. T.
Title A phase-specific neuroimmune model of clinical depression
Journal name Progress in Neuro-Psychopharmacology and Biological Psychiatry   Check publisher's open access policy
ISSN 0278-5846
1878-4216
Publication date 2014-10-03
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.pnpbp.2014.06.011
Open Access Status DOI
Volume 54
Start page 265
End page 274
Total pages 10
Place of publication Philadelphia, PA United States
Publisher Elsevier Inc.
Language eng
Subject 3004 Pharmacology
2803 Biological Psychiatry
Abstract Immune dysfunction and pro-inflammatory states in particular have been implicated in the aetiology and pathogenesis of depression. Whilst the onset of an episode and certain symptoms of depression appear well explained by this inflammatory model, the underpinnings of the episodic and progressive nature, as well as relapse and remission status in depression require attention. In this review it is suggested that additional immune factors beyond pro- and anti-inflammatory cytokines may effectively contribute to the understanding of the neurobiology of clinical depression. Considering neurobiological effects of immunomodulatory factors such as T cells, macrophages, microglia and astrocytes relevant to depression, we suggest a neuroimmune model of depression underpinned by dynamic immunomodulatory processes. This perspective paper then outlines a neuroimmune model of clinical phases of depression in an attempt to more adequately explain depression-like behaviours in pre-clinical models and the dynamic nature of depression in clinical populations. Finally, the implications for immunomodulatory treatments of depression are considered.
Keyword Cytokine
Depression
Immune
Inflammation
Model
Staging
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
 
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