The clinical spectrum of anxiety in Parkinson's disease

Dissanayaka, Nadeeka N. N. W., White, Elizabeth, O'Sullivan, John D., Marsh, Rodney, Pachana, Nancy A. and Byrne, Gerard J. (2014) The clinical spectrum of anxiety in Parkinson's disease. Movement Disorders, 29 8: 967-975. doi:10.1002/mds.25937

Author Dissanayaka, Nadeeka N. N. W.
White, Elizabeth
O'Sullivan, John D.
Marsh, Rodney
Pachana, Nancy A.
Byrne, Gerard J.
Title The clinical spectrum of anxiety in Parkinson's disease
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
Publication date 2014-07-01
Sub-type Article (original research)
DOI 10.1002/mds.25937
Volume 29
Issue 8
Start page 967
End page 975
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Anxiety is common in Parkinson's disease (PD), and contributes to increased disability and poorer quality of life. In spite of its significant impact, the symptomatology, chronology, and neurobiology of anxiety in PD are all poorly understood, and this hinders accurate diagnosis and development of effective treatment strategies. This review investigates and updates literature related to the clinical spectrum of anxiety in PD. The reported prevalence of anxiety in PD varies considerably, with emerging interest in the frequency of the DSM-IV residual category of “Anxiety disorder, not otherwise specified” (Anxiety disorder NOS), which is observed in up to 25% of PD patients. By design, there are no standardized diagnostic criteria for Anxiety disorder NOS, because this is the category applied to individuals who do not meet diagnostic criteria for any other current anxiety disorder. Anxiety rating scales incompletely capture anxiety symptoms that relate specifically to PD symptoms and the complications arising from PD therapy. Consequently, these scales have been deemed inappropriate for use in PD, and there remains a need for the development of a new PD-specific anxiety scale. Research establishing accurate symptom profiles of anxiety in PD is sparse, although characterizing such symptomatology would likely improve clinical diagnosis and facilitate targeted treatment strategies. Research into the neurobiological and psychological underpinnings of anxiety in PD remains inconclusive. Anxiety can precede the onset of PD motor symptoms or can develop after a diagnosis of PD. Further investigations focused on the chronology of anxiety and its relationship to PD diagnosis are required.
Keyword Anxiety
Parkinson's disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 25 Jul 2014, 22:57:59 EST by Sheila Cleary on behalf of UQ Centre for Clinical Research