Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age

Zosky G.R., Hart P.H., Whitehouse A.J.O., Kusel M.M., Ang W., Foong R.E., Chen L., Holt P.G., Sly P.D. and Hall G.L. (2014) Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age. Annals of the American Thoracic Society, 11 4: 571-577. doi:10.1513/AnnalsATS.201312-423OC


Author Zosky G.R.
Hart P.H.
Whitehouse A.J.O.
Kusel M.M.
Ang W.
Foong R.E.
Chen L.
Holt P.G.
Sly P.D.
Hall G.L.
Title Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age
Journal name Annals of the American Thoracic Society   Check publisher's open access policy
ISSN 2325-6621
2329-6933
Publication date 2014-01-01
Sub-type Article (original research)
DOI 10.1513/AnnalsATS.201312-423OC
Open Access Status Not yet assessed
Volume 11
Issue 4
Start page 571
End page 577
Total pages 7
Place of publication New York, NY, U.S.A.
Publisher American Thoracic Society
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
Abstract Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency during the early stages of lung development and postnatal lung function in human populations. Objectives: To assess the association between maternal vitamin D deficiency, postnatal lung function, and asthmatic status in a longitudinal birth cohort. Methods: Serum was collected at 16 to 20 weeks' gestation at the time of recruitment in a community-based prospective birth cohort for measurement of vitamin D (25[OH]D). Lung function was assessed by spirometry according to American Thoracic Society guidelines in children at 6 and 14 years of age. Demographic and clinical history data were collected by questionnaire at recruitment and at the follow-up visits. Measurements and Main Results: FVC Z-scores in both sexes (β, 0.007 [95% confidence interval (CI), 0.001-0.013]; P = 0.02) and FEV1 Z-scores in girls (β, 0.007 [95% CI, 0.001-0.013]; P = 0.02) were positively associated with maternal serum 25(OH)D at 6 years of age. These associations were mostly absent at 14 years of age. Maternal vitamin D deficiency was positively associated with asthma at 6 years of age but only in boys (odds ratio, 3.03 [95% CI, 1.02-9.02]; P = 0.04). Conclusions: This study supports the notion that vitamin D deficiency during lung development may impact on postnatal lung growth and increase the risk of developing lung disease. Copyright
Keyword 25(OH)D
FVC
Lung development
Raine Study
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
 
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