Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation

Delattin, Nicolas, De Brucker, Katrijn, Craik, David J., Cheneval, Olivier, De Coninck, Barbara, Cammue, Bruno P. A. and Thevissen, Karin (2014) Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation. Antimicrobial Agents and Chemotherapy, 58 8: 4974-4977. doi:10.1128/AAC.03336-14

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ334756_OA.pdf Full text (open access) application/pdf 310.66KB 0

Author Delattin, Nicolas
De Brucker, Katrijn
Craik, David J.
Cheneval, Olivier
De Coninck, Barbara
Cammue, Bruno P. A.
Thevissen, Karin
Title Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation
Formatted title
Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
1098-6596
Publication date 2014-08-01
Year available 2014
Sub-type Article (original research)
DOI 10.1128/AAC.03336-14
Open Access Status File (Publisher version)
Volume 58
Issue 8
Start page 4974
End page 4977
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2015
Language eng
Formatted abstract
We performed a structure-activity relationship study of the antibiofilm plant-derived decapeptide OSIP108. Introduction of positively charged amino acids R, H, and K resulted in an up-to-5-fold-increased antibiofilm activity against Candida albicans compared to native OSIP108, whereas replacement of R9 resulted in complete abolishment of its antibiofilm activity. By combining the most promising amino acid substitutions, we found that the double-substituted OSIP108 analogue Q6R/G7K had an 8-fold-increased antibiofilm activity.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 17 Jul 2014, 00:29:48 EST by Susan Allen on behalf of Institute for Molecular Bioscience