A retrospective study of volume doubling time in surgically resected non-small cell lung cancer

Mackintosh, John A., Marshall, Henry M., Yang, Ian A., Bowman, Rayleen V. and Fong, Kwun M. (2014) A retrospective study of volume doubling time in surgically resected non-small cell lung cancer. Respirology, 19 5: 755-762. doi:10.1111/resp.12311


Author Mackintosh, John A.
Marshall, Henry M.
Yang, Ian A.
Bowman, Rayleen V.
Fong, Kwun M.
Title A retrospective study of volume doubling time in surgically resected non-small cell lung cancer
Journal name Respirology   Check publisher's open access policy
ISSN 1440-1843
1323-7799
Publication date 2014-07-01
Year available 2014
Sub-type Article (original research)
DOI 10.1111/resp.12311
Volume 19
Issue 5
Start page 755
End page 762
Total pages 8
Place of publication Richmond, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Background and objective
Volume doubling time (VDT) contributes to the evaluation of the indeterminate pulmonary nodule, an increasingly frequent problem given the rising use of computed tomography (CT). We aimed to correlate patient and tumour characteristics with VDT and growth rates of primary non-small cell lung cancers (NSCLC).

Methods
Surgically treated NSCLC, which underwent two or more CT scans separated by 25 or more days were studied. Tumour volume was measured using semi-automated volumetric software. VDT and growth rate (1/VDT) were correlated with patient and tumour characteristics.

Results
Thirty-six adenocarcinomas (AC), six squamous cell carcinoma (SCC), two large cell and two carcinoids in 46 patients had 109 eligible scans. Median VDT was 191 days (range −9435 to 2256 days); median growth rate was 0.0038 (range −0.0086 to 0.0186). Median growth rate of AC was significantly slower than SCC (0.0034 vs 0.0103, P = 0.037). Nine AC had VDT >400 days, three of which developed distant metastases. Median growth rate of AC was faster in smokers compared with never-smokers (0.0052 vs 0.0014, P = 0.02). Growth rate was not related to symptoms at diagnosis (P = 0.16). Less differentiated tumours tended to grow faster than more differentiated (P = 0.0038). Growth curves of 12 multi-imaged tumours conformed best with the exponential model of growth.

Conclusions
NSCLC growth rate appears to be highly variable and related to histological subtype and smoking history, but not the presence of symptoms at diagnosis. Significant growth may be detected in as little as 2 months in NSCLC in smokers. Relatively slow-growing AC can metastasize.
Keyword Adenocarcinoma
Lung neoplasm
Non-small cell lung cancer
Time factor
Tomography
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 15 Jul 2014, 13:31:38 EST by System User on behalf of Medicine - Prince Charles Hospital