Noninvasive quantification of hepatic steatosis: relationship between obesity status and liver fat content

McLeay, S. C., Morrish, G. A., Ponnuswamy, T. K., Devanand, B., Ramanathan, M., Venkatakrishnan, L., Ramalingam, S. and Green, B. (2014) Noninvasive quantification of hepatic steatosis: relationship between obesity status and liver fat content. Open Obesity Journal, 6 1: 16-24. doi:10.2174/1876823701406010016


Author McLeay, S. C.
Morrish, G. A.
Ponnuswamy, T. K.
Devanand, B.
Ramanathan, M.
Venkatakrishnan, L.
Ramalingam, S.
Green, B.
Title Noninvasive quantification of hepatic steatosis: relationship between obesity status and liver fat content
Journal name Open Obesity Journal   Check publisher's open access policy
ISSN 1876-8237
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.2174/1876823701406010016
Open Access Status DOI
Volume 6
Issue 1
Start page 16
End page 24
Total pages 9
Place of publication Bussum, Netherlands
Publisher Bentham Open
Language eng
Formatted abstract
The aim of this study was to assess and compare fat content within the liver for normal (body mass index (BMI) < 25 kg/m2), overweight (25-30 kg/m2) and obese (≥ 30 kg/m2) subjects using a noninvasive, non-contrast computed tomography (CT) quantification method. Adult subjects aged 18-60 yrs scheduled to undergo CT examination of the abdominal region were recruited for this study, stratified across BMI categories. Liver volume, fat content, and lean liver volume were determined using CT methods. A total of 100 subjects were recruited, including 30 normal weight, 31 overweight, and 39 obese. Total liver volume increased with BMI, with mean values of 1138 ± 277, 1374 ± 331, and 1766 ± 389 cm3 for the normal, overweight, and obese, respectively (P < 0.001), which was due to an increase in both liver fat content and lean liver volume with BMI. Some obese subjects had no or minimal hepatic fat content. The prevalence of mild fatty liver in this study of 100 subjects was overestimated for all BMI categories using a range of qualitative diagnostic measures, with predicted prevalence of fatty liver in obese subjects ranging from 76.9% for liver-to-spleen ratio ≤ 1.1 to 89.7% for liver attenuation index (liver HU - spleen HU) ≤ 40, compared to 66.7% by quantification of fat content. Results show that total liver volume increases with BMI, however, not all obese subjects display fatty infiltration of the liver. CT quantification of liver fat content may be suitable for accurate diagnosis of hepatic steatosis in clinical practice and assessment of donor livers for transplantation.
Keyword Body mass index
Computed tomography
Fatty liver
Hepatic steatosis
Obesity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Pharmacy Publications
 
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