Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

Rogers, G. B., Kozlowska, J., Keeble, J., Metcalfe, K., Fao, M., Dowd, S. E., Mason, A. J., McGuckin, M. A. and Bruce, K. D. (2014) Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice. Scientific Reports, 4 . doi:10.1038/srep05437


Author Rogers, G. B.
Kozlowska, J.
Keeble, J.
Metcalfe, K.
Fao, M.
Dowd, S. E.
Mason, A. J.
McGuckin, M. A.
Bruce, K. D.
Title Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2014-06-25
Year available 2014
Sub-type Article (original research)
DOI 10.1038/srep05437
Open Access Status DOI
Volume 4
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Groups
Collection year 2015
Language eng
Formatted abstract
Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2015 Collection
 
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