Lung function, airway inflammation, and polycyclic aromatic hydrocarbons exposure in mexican schoolchildren: A pilot study

Barraza-Villarreal, Albino, Escamilla-Nunez, Maria Consuelo, Schilmann, Astrid, Hernandez-Cadena, Leticia, Li, Zheng, Romanoff, Lovisa, Sjodin, Andreas, Del Rio-Navarro, Blanca Estela, Diaz-Sanchez, David, Diaz-Barriga, Fernando, Sly, Peter and Romieu, Isabelle (2014) Lung function, airway inflammation, and polycyclic aromatic hydrocarbons exposure in mexican schoolchildren: A pilot study. Journal of Occupational and Environmental Medicine, 56 4: 415-419. doi:10.1097/JOM.0000000000000111

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Author Barraza-Villarreal, Albino
Escamilla-Nunez, Maria Consuelo
Schilmann, Astrid
Hernandez-Cadena, Leticia
Li, Zheng
Romanoff, Lovisa
Sjodin, Andreas
Del Rio-Navarro, Blanca Estela
Diaz-Sanchez, David
Diaz-Barriga, Fernando
Sly, Peter
Romieu, Isabelle
Title Lung function, airway inflammation, and polycyclic aromatic hydrocarbons exposure in mexican schoolchildren: A pilot study
Journal name Journal of Occupational and Environmental Medicine   Check publisher's open access policy
ISSN 1536-5948
1076-2752
Publication date 2014-04-01
Year available 2014
Sub-type Article (original research)
DOI 10.1097/JOM.0000000000000111
Volume 56
Issue 4
Start page 415
End page 419
Total pages 5
Place of publication Philadelphia United States
Publisher Lippincott Williams and Wilkins
Language eng
Formatted abstract
 Objective:
To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren.

Methods:
A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models.

Results:
A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (-11.2 mL, 95% CI:-22.2 to-0.02), forced vital capacity (-11.6 mL, 95% CI:-22.9 to-0.2), and pH of EBC (-0.035, 95% CI:-0.066 to-0.005).

Conclusion:
Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
Official Audit
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
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