Nucleotide sequences of Australian isolates of the feline immunodeficiency virus: comparison with other feline lentiviruses

Greene W.K., Meers J., Chadwick B., Carnegie P.R. and Robinson W.F. (1993) Nucleotide sequences of Australian isolates of the feline immunodeficiency virus: comparison with other feline lentiviruses. Archives of Virology, 132 3-4: 369-379. doi:10.1007/BF01309546


Author Greene W.K.
Meers J.
Chadwick B.
Carnegie P.R.
Robinson W.F.
Title Nucleotide sequences of Australian isolates of the feline immunodeficiency virus: comparison with other feline lentiviruses
Journal name Archives of Virology   Check publisher's open access policy
ISSN 0304-8608
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1007/BF01309546
Volume 132
Issue 3-4
Start page 369
End page 379
Total pages 11
Publisher Springer-Verlag
Language eng
Subject 1311 Genetics
2402 Applied Microbiology and Biotechnology
Abstract Proviral DNA from four Australian isolates of feline immunodeficiency virus (FIV) was amplified by PCR and the nucleotide sequence determined for two conserved regions within gag (p 15/p 24) and pol (RT) genes. Comparison with the nucleotide and deduced amino acid sequence of two previously described U.S. isolates from California (Petaluma and PPR), and a third from Maryland (MD) as well as the Japanese isolate TM 2, revealed a close similarity between the Australian and Californian isolates with 95-97% nucleotide and 96-99% amino acid homologies. By contrast, the Maryland and Japanese isolates were more distantly related with only 84-87% nucleotide and 90-94% amino acid homology with either the Australian or Californian isolates. The relationship of the Australian FIV isolates to other domestic isolates as well as eight lentiviral isolates from wild felidae (panthers) published previously, was investigated further by constructing a phylogenetic tree based on the pol sequence. This revealed two subgroups of FIV, an Australian/Californian group and a less tightly clustered Maryland/Japanese group. These results suggest that the genomic variability of FIV is reflected by more than simply geographic distance. Furthermore, the relative genetic homogeneity found between Australian isolates suggest a shorter period of evolution of the virus in Australia than in North America.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: ResearcherID Downloads
Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 26 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 23 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 09 Jul 2014, 20:08:25 EST by System User