Genome- and proteome-wide screening strategies for antigen discovery and immunogen design

Schussek, Sophie, Trieu, Angela and Doolan, Denise L. (2014) Genome- and proteome-wide screening strategies for antigen discovery and immunogen design. Biotechnology Advances, 32 2: 403-414. doi:10.1016/j.biotechadv.2013.12.006


Author Schussek, Sophie
Trieu, Angela
Doolan, Denise L.
Title Genome- and proteome-wide screening strategies for antigen discovery and immunogen design
Journal name Biotechnology Advances   Check publisher's open access policy
ISSN 0734-9750
1873-1899
Publication date 2014-03-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.biotechadv.2013.12.006
Open Access Status Not Open Access
Volume 32
Issue 2
Start page 403
End page 414
Total pages 12
Place of publication New York, NY, United States
Publisher Elsevier
Language eng
Abstract Infectious diseases remain a leading global cause of morbidity and mortality and there is an urgent need for effective approaches to develop vaccines, especially against complex pathogens. The availability of comprehensive genomic, proteomic and transcriptomic datasets has shifted the paradigm of vaccine development from microbiological to sequence-based approaches. However, how to effectively translate raw data into candidate vaccines is not yet obvious. Herein, we review cutting-edge technologies and screening strategies to mine genomic sequence information for state-of-the-art rational vaccine design, and highlight recent trends. Interdisciplinary approaches which cross the traditional boundaries of genomics, molecular biology, cell biology, immunology and computer science, and which prioritise antigens according to clinically relevant criteria, offer potential solutions to the widespread threat that complex pathogens pose to public health.
Keyword Reverse vaccinology
Immunomics
Immune profiling
Vaccinomics
Protection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication date: March–April 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
 
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