High anti-viral protection without immune upregulation after interspecies Wolbachia transfer

Chrostek, Ewa, Marialva, Marta S. P., Yamada, Ryuichi, O'Neill, Scott L. and Teixeira, Luis (2014) High anti-viral protection without immune upregulation after interspecies Wolbachia transfer. PLoS One, 9 6: e99025.1-e99025.7. doi:10.1371/journal.pone.0099025


Author Chrostek, Ewa
Marialva, Marta S. P.
Yamada, Ryuichi
O'Neill, Scott L.
Teixeira, Luis
Title High anti-viral protection without immune upregulation after interspecies Wolbachia transfer
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-06-09
Year available 2014
Sub-type Article (original research)
DOI 10.1371/journal.pone.0099025
Open Access Status DOI
Volume 9
Issue 6
Start page e99025.1
End page e99025.7
Total pages 7
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Abstract Wolbachia, endosymbionts that reside naturally in up to 40-70% of all insect species, are some of the most prevalent intracellular bacteria. Both Wolbachia wAu, naturally associated with Drosophila simulans, and wMel, native to Drosophila melanogaster, have been previously described to protect their hosts against viral infections. wMel transferred to D. simulans was also shown to have a strong antiviral effect. Here we directly compare one of the most protective wMel variants and wAu in D. melanogaster in the same host genetic background. We conclude that wAu protects better against viral infections, it grows exponentially and significantly shortens the lifespan of D. melanogaster . However, there is no difference between wMel and wAu in the expression of selected antimicrobial peptides. Therefore, neither the difference in anti-viral effect nor the life-shortening could be attributed to the immune stimulation by exogenous Wolbachia. Overall, we prove that stable transinfection with a highly protective Wolbachia is not necessarily associated with general immune activation.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biological Sciences Publications
 
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