Volumetrics relate to the development of depression after traumatic brain injury

Maller, Jerome J., Thomson, Richard H. S., Pannek, Kerstin, Bailey, Neil, Lewis, Philip M. and Fitzgerald, Paul B. (2014) Volumetrics relate to the development of depression after traumatic brain injury. Behavioural Brain Research, 271 147-153. doi:10.1016/j.bbr.2014.05.047


Author Maller, Jerome J.
Thomson, Richard H. S.
Pannek, Kerstin
Bailey, Neil
Lewis, Philip M.
Fitzgerald, Paul B.
Title Volumetrics relate to the development of depression after traumatic brain injury
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 1872-7549
0166-4328
Publication date 2014-09-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.bbr.2014.05.047
Open Access Status Not Open Access
Volume 271
Start page 147
End page 153
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Previous research suggests that many people who sustain a traumatic brain injury (TBI), even of the mild form, will develop major depression (MD). We previously reported white matter integrity differences between those who did and did not develop MD after mild TBI. In this current paper, we aimed to investigate whether there were also volumetric differences between these groups, as suggested by previous volumetric studies in mild TBI populations. A sample of TBI-with-MD subjects (N = 14), TBI-without-MD subjects (N = 12), MD-without-TBI (N = 26) and control subjects (no TBI or MD, N = 23), received structural MRI brain scans. T1-weighted data were analysed using the Freesurfer software package which produces automated volumetric results. The findings of this study indicate that (1) TBI patients who develop MD have reduced volume in temporal, parietal and lingual regions compared to TBI patients who do not develop MD, and (2) MD patients with a history of TBI have decreased volume in the temporal region compared to those who had MD but without a history of TBI. We also found that more severe MD in those with TBI-with-MD significantly correlated with reduced volume in anterior cingulate, temporal lobe and insula. These findings suggest that volumetric reduction to specific regions, including parietal, temporal and occipital lobes, after a mild TBI may underlie the susceptibility of these patients developing major depression, in addition to altered white matter integrity.
Keyword Brain injury
Major depression
Volume
Neuroimaging
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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