Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies

You, Hong, Stephenson, Rachel J., Gobert, Geoffrey N. and McManus, Donald P. (2014) Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies. Frontiers in Genetics, 5 JUN: . doi:10.3389/fgene.2014.00176

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Author You, Hong
Stephenson, Rachel J.
Gobert, Geoffrey N.
McManus, Donald P.
Title Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies
Journal name Frontiers in Genetics   Check publisher's open access policy
ISSN 1664-8021
Publication date 2014-06-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fgene.2014.00176
Open Access Status DOI
Volume 5
Issue JUN
Total pages 8
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract A better understanding of the molecular mechanisms required for schistosomes to take up glucose, the major nutritional source exploited by these blood flukes from their mammalian hosts and the subsequent metabolism required to fuel growth and fecundity, can provide new avenues for developing novel interventions for the control of schistosomiasis. This aspect of parasitism is particularly important to paired adult schistosomes, due to their considerable requirements for the energy needed to produce the extensive numbers of eggs laid daily by the female worm. This review describes recent advances in characterizing glucose metabolism in adult schistosomes. Potential intervention targets are discussed within the insulin signaling and glycolysis pathways, both of which play critical roles in the carbohydrate and energy requirements of schistosomes.
Keyword Schistosome
Schistosoma
Glucose uptake and metabolism
Insulin signalling pathway
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 176

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Official Audit
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 04 Jul 2014, 20:18:32 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences