Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses

Simerska, Pavla, Suksamran, Tittaya, Ziora, Zyta Maria, Rivera, Fabian de Labastida, Engwerda, Christian and Toth, Istvan (2014) Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses. Vaccine, 32 37: 4743-4750. doi:10.1016/j.vaccine.2014.06.049


Author Simerska, Pavla
Suksamran, Tittaya
Ziora, Zyta Maria
Rivera, Fabian de Labastida
Engwerda, Christian
Toth, Istvan
Title Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses
Formatted title
Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
1873-2518
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2014.06.049
Open Access Status Not Open Access
Volume 32
Issue 37
Start page 4743
End page 4750
Total pages 8
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
The lipid core peptide (LCP) system has successfully been used in development of peptide-based vaccines against cancer and infectious diseases (such as group A streptococcal infection). CD8 + T cells are important targets for vaccines, however developing a vaccine that activates long-lasting immunity has proven challenging. The ability of LCP vaccines to activate antigen-specific CD8 + and/or CD4 + T cell responses was tested using compounds that contained two or four copies of OVA 257–264 and/or OVA 323–339 peptides conjugated to LCP, which are recognised by OTI (CD8 + specific) and OTII (CD4 + specific) T cells, respectively. The LCP–ovalbumin vaccines developed in this study were synthesised in 30% yields and showed no significant haemolytic effect on red blood cells (below 4% haemolysis when tested with compounds at up to 100 μM concentrations). Promising in vivo data in mice suggested that this LCP–ovalbumin vaccine system could act as a novel and potent vehicle for the stimulation of robust antigen-specific CD8 + T cell responses.
Keyword Ovalbumin
Peptide synthesis
Vaccine development
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DP1092829
Institutional Status UQ
Additional Notes Published online ahead of print 23 June 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
 
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Created: Fri, 04 Jul 2014, 19:53:16 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences