Dual acquisition of (18)F-FMISO and (18)F-FDOPA

Bell, Christopher, Rose, Stephen, Puttick, Simon, Pagnozzi, Alex, Poole, Christopher M., Gal, Yaniv, Thomas, Paul, Fay, Michael, Jeffree, Rosalind L. and Dowson, Nicholas (2014) Dual acquisition of (18)F-FMISO and (18)F-FDOPA. Physics in Medicine and Biology, 59 14: 3925-3949. doi:10.1088/0031-9155/59/14/3925

Author Bell, Christopher
Rose, Stephen
Puttick, Simon
Pagnozzi, Alex
Poole, Christopher M.
Gal, Yaniv
Thomas, Paul
Fay, Michael
Jeffree, Rosalind L.
Dowson, Nicholas
Title Dual acquisition of (18)F-FMISO and (18)F-FDOPA
Formatted title
Dual acquisition of 18F-FMISO and 18F-FDOPA
Journal name Physics in Medicine and Biology   Check publisher's open access policy
ISSN 0031-9155
Publication date 2014-07-21
Year available 2014
Sub-type Article (original research)
DOI 10.1088/0031-9155/59/14/3925
Open Access Status Not Open Access
Volume 59
Issue 14
Start page 3925
End page 3949
Total pages 25
Place of publication Temple Back, Bristol, United Kingdom
Publisher Institute of Physics Publishing
Language eng
Formatted abstract
Metabolic imaging using positron emission tomography (PET) has found increasing clinical use for the management of infiltrating tumours such as glioma. However, the heterogeneous biological nature of tumours and intrinsic treatment resistance in some regions means that knowledge of multiple biological factors is needed for effective treatment planning. For example, the use of 18F-FDOPA to identify infiltrative tumour and 18F-FMISO for localizing hypoxic regions. Performing multiple PET acquisitions is impractical in many clinical settings, but previous studies suggest multiplexed PET imaging could be viable. The fidelity of the two signals is affected by the injection interval, scan timing and injected dose. The contribution of this work is to propose a framework to explicitly trade-off signal fidelity with logistical constraints when designing the imaging protocol. The particular case of estimating 18F-FMISO from a single frame prior to injection of 18F-FDOPA is considered. Theoretical experiments using simulations for typical biological scenarios in humans demonstrate that results comparable to a pair of single-tracer acquisitions can be obtained provided protocol timings are carefully selected. These results were validated using a pre-clinical data set that was synthetically multiplexed. The results indicate that the dual acquisition of 18F-FMISO and 18F-FDOPA could be feasible in the clinical setting. The proposed framework could also be used to design protocols for other tracers.
Keyword Engineering, Biomedical
Radiology, Nuclear Medicine & Medical Imaging
Radiology, Nuclear Medicine & Medical Imaging
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 631567
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 02 Jul 2014, 02:03:23 EST by Simon Puttick on behalf of Aust Institute for Bioengineering & Nanotechnology