Aldosterone excess and resistant hypertension: investigation and treatment

Stowasser, Michael (2014) Aldosterone excess and resistant hypertension: investigation and treatment. Current Hypertension Reports, 16 7: 1-11. doi:10.1007/s11906-014-0439-7

Author Stowasser, Michael
Title Aldosterone excess and resistant hypertension: investigation and treatment
Journal name Current Hypertension Reports   Check publisher's open access policy
ISSN 1534-3111
Publication date 2014-05-01
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s11906-014-0439-7
Open Access Status Not yet assessed
Volume 16
Issue 7
Start page 1
End page 11
Total pages 11
Place of publication Philadelphia PA, United States
Publisher Springer Healthcare
Language eng
Abstract Among patients with resistant hypertension, primary aldosteronism (PA) is worth detecting as it appears to be particularly common in this cohort. It is associated with excessive cardiovascular morbidity in relation to the degree of hypertension and reduced quality of life, both of which can be abrogated with specific surgical or medical treatment. Knowledge concerning factors (including medications) which can influence the results of screening by aldosterone/renin ratio (ARR) testing is expanding, and is important to appreciate, particularly in patients with resistant hypertension, in whom the need for multiple medications can render interpretation challenging. Advances in approaches to confirmatory testing, subtype differentiation and assay methodology are helping to improve feasibility and reliability of the diagnostic workup for PA and new treatment approaches are emerging. Major developments in understanding the genetic bases for PA hold promise towards further improvements and options in diagnosis and therapy.
Keyword Aldosterone
Primary aldosteronism
Quality of life
Aldosterone/renin ratio
Subtype differentiation
Adrenal venous sampling
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
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