Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression

Escobar, Giulia, Gentner, Bernhard, Naldini, Luigi and Mazzieri, Roberta (2014) Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression. OncoImmunology, 3 5: e28696-1-e28696-3. doi:10.4161/onci.28696

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Author Escobar, Giulia
Gentner, Bernhard
Naldini, Luigi
Mazzieri, Roberta
Title Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
Journal name OncoImmunology   Check publisher's open access policy
ISSN 2162-4011
2162-402X
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.4161/onci.28696
Volume 3
Issue 5
Start page e28696-1
End page e28696-3
Total pages 3
Place of publication Austin, TX United States
Publisher Landes Bioscience
Language eng
Abstract An immunosuppressive tumor microenvironment is a cancer hallmark and a major impediment to successful immunotherapy. We engineered hematopoietic progenitors to target expression of an interferon-α (IFNα) transgene specifically to their monocytic progeny, including tumor-infiltrating macrophages. Mice chimeric for these IFNα-expressing macrophages showed activation of innate and adaptive immune cells against breast cancer and inhibited disease progression.
Keyword Breast cancer
Gene transfer strategy
IFN α delivery
Immunosuppressive microenvironment
Tumour associated macrophages
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
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Created: Tue, 01 Jul 2014, 12:54:42 EST by System User on behalf of UQ Diamantina Institute