Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum

Suarez, Rodrigo, Fenlon, Laura R., Marek, Roger, Avitan, Lilach A, Sah, Pankaj, Goodhill, Geoffrey J. and Richards, Linda J. (2014) Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum. Neuron, 82 6: 1289-1298. doi:10.1016/j.neuron.2014.04.040

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Author Suarez, Rodrigo
Fenlon, Laura R.
Marek, Roger
Avitan, Lilach A
Sah, Pankaj
Goodhill, Geoffrey J.
Richards, Linda J.
Title Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum
Journal name Neuron   Check publisher's open access policy
ISSN 1097-4199
0896-6273
Publication date 2014-06-18
Sub-type Article (original research)
DOI 10.1016/j.neuron.2014.04.040
Open Access Status File (Author Post-print)
Volume 82
Issue 6
Start page 1289
End page 1298
Total pages 10
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Abstract Bilateral integration of sensory and associative brain processing is achieved by precise connections between homologous regions in the two hemispheres via the corpus callosum. These connections form postnatally, and unilateral deprivation of sensory or spontaneous cortical activity during a critical period severely disrupts callosal wiring. However, little is known about how this early activity affects precise circuit formation. Here, using in utero electroporation of reporter genes, optogenetic constructs, and direct disruption of activity in callosal neurons combined with whisker ablations, we show that balanced interhemispheric activity, and not simply intact cortical activity in either hemisphere, is required for functional callosal targeting. Moreover, bilateral ablation of whiskers in symmetric or asymmetric configurations shows that spatially symmetric interhemispheric activity is required for appropriate callosal targeting. Our findings reveal a principle governing axon targeting, where spatially balanced activity between regions is required to establish their appropriate connectivity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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