Malaria drives T cells to exhaustion

Wykes, Michelle N., Horne-Debets, Joshua M., Leow, Chiuan-Yee and Karunarathne, Deshapriya S. (2014) Malaria drives T cells to exhaustion. Frontiers in Microbiology, 5 . doi:10.3389/fmicb.2014.00249


Author Wykes, Michelle N.
Horne-Debets, Joshua M.
Leow, Chiuan-Yee
Karunarathne, Deshapriya S.
Title Malaria drives T cells to exhaustion
Journal name Frontiers in Microbiology   Check publisher's open access policy
ISSN 1664-302X
Publication date 2014-05-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fmicb.2014.00249
Open Access Status DOI
Volume 5
Total pages 5
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Formatted abstract
Malaria is a significant global burden but after >30 years of effort there is no vaccine on the market. While the complex life cycle of the parasite presents several challenges, many years of research have also identified several mechanisms of immune evasion by Plasmodium spp. Recent research on malaria, has investigated the programmed cell death-1 (PD-1) pathway which mediates exhaustion of T cells, characterized by poor effector functions and recall responses and in some cases loss of the cells by apoptosis. Such studies have shown exhaustion of CD4+ T cells and an unappreciated role for CD8+ T cells in promoting sterile immunity against blood stage malaria. This is because PD-1 mediates up to a 95% reduction in numbers and functional capacity of parasite-specific CD8+ T cells, thus masking their role in protection. The role of T cell exhaustion during malaria provides an explanation for the absence of sterile immunity following the clearance of acute disease which will be relevant to future malaria-vaccine design and suggests the need for novel therapeutic solutions. This review will thus examine the role of PD-1-mediated T cell exhaustion in preventing lasting immunity against malaria.
Keyword CD8(+) T cell
Malaria
Exhaustion
Pd-1
Chronic disease
CD4(+) T cells
B cells
Pd-L1
Blood-stage malaria
Plasmodium falciparum
Acquired immunity
B-Cells
Lymphocyte activation
Pd-1 expression
Hcv infection
Blockade
Responses
Mice
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article 249

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
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