Modification of ibuprofen drug release from poly(ethylene glycol) layered silicate nanocomposites prepared by hot-melt extrusion

Campbell, Kayleen T., Craig, Duncan Q.M. and McNally, Tony (2014) Modification of ibuprofen drug release from poly(ethylene glycol) layered silicate nanocomposites prepared by hot-melt extrusion. Journal of Applied Polymer Science, 131 10: e40284.1-e40284.7. doi:10.1002/app.40284


Author Campbell, Kayleen T.
Craig, Duncan Q.M.
McNally, Tony
Title Modification of ibuprofen drug release from poly(ethylene glycol) layered silicate nanocomposites prepared by hot-melt extrusion
Journal name Journal of Applied Polymer Science   Check publisher's open access policy
ISSN 0021-8995
1097-4628
Publication date 2014-05-15
Year available 2013
Sub-type Article (original research)
DOI 10.1002/app.40284
Open Access Status Not Open Access
Volume 131
Issue 10
Start page e40284.1
End page e40284.7
Total pages 7
Place of publication Hoboken United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Composites of the poorly water soluble drug ibuprofen, a nonsteroidal anti-inflammatory commonly used for pain relief, with layered silicates (nanoclays) and a poly(ethylene glycol) (PEG) were prepared by hot melt extrusion. A highly intercalated and partially exfoliated morphology was determined using wide-angle x-ray diffraction, field emission scanning electron microscopy, and high-resolution transmission electron microscopy. The crystalline content of PEG was significantly reduced, as shown by differential scanning calorimetry studies, as a consequence of the large surface area of clay platelets physically hindering polymer chain dynamics and, in the case of montmorillonite, by tethering of PEG via hydrogen bonding. Addition of layered silicate retarded the release of ibuprofen from the PEG matrix, even though the crystalline content of PEG was reduced. This study therefore indicates that drug release in solid dispersion systems may be modified or indeed tailored by the inclusion of layered silicates.
Keyword Biomaterials
Biomedical applications
Drug delivery systems
Nanoparticles
Nanowires and nanocrystals
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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