Metallo-beta-lactamases and their biomimetic complexes

Daumann, Lena J., Schenk, Gerhard and Gahan, Lawrence R. (2014) Metallo-beta-lactamases and their biomimetic complexes. European Journal of Inorganic Chemistry, 2014 18: 2869-2885. doi:10.1002/ejic.201402203

Author Daumann, Lena J.
Schenk, Gerhard
Gahan, Lawrence R.
Title Metallo-beta-lactamases and their biomimetic complexes
Formatted title
Metallo-β-lactamases and their biomimetic complexes
Journal name European Journal of Inorganic Chemistry   Check publisher's open access policy
ISSN 1434-1948
Publication date 2014-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/ejic.201402203
Volume 2014
Issue 18
Start page 2869
End page 2885
Total pages 17
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag
Language eng
Formatted abstract
In order to treat bacterial infections successfully in the future, the mechanism of action of metallo-β-lactamases (MβLs) needs to be fully understood so that clinically useful inhibitors and new therapeutic approaches can be developed. This microreview describes recent developments and the achievements towards the design of MβL biomimetics to aid in the mechanistic and structural understanding of these enzyme systems. We highlight the known inhibitors and substrates employed in these studies, the different ligands and complexes employed, and the experimental and computational studies undertaken to explore the possible mechanisms of action of the MβLs.
Keyword Metallo-β-lactamases
Enzyme models
Antibiotic resistance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 27 Jun 2014, 21:57:54 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences