Preparation of cellulose based microspheres by combining spray coagulating with spray drying

Wang, Qiao, Fu, Aiping, Li, Hongliang, Liu, Jingquan, Guo, Peizhi, Zhao, Xiu Song and Xia, Lin Hua (2014) Preparation of cellulose based microspheres by combining spray coagulating with spray drying. Carbohydrate Polymers, 111 393-399. doi:10.1016/j.carbpol.2014.05.002


Author Wang, Qiao
Fu, Aiping
Li, Hongliang
Liu, Jingquan
Guo, Peizhi
Zhao, Xiu Song
Xia, Lin Hua
Title Preparation of cellulose based microspheres by combining spray coagulating with spray drying
Journal name Carbohydrate Polymers   Check publisher's open access policy
ISSN 0144-8617
1879-1344
Publication date 2014-10-13
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.carbpol.2014.05.002
Open Access Status Not Open Access
Volume 111
Start page 393
End page 399
Total pages 7
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract Porous microspheres of regenerated cellulose with size in range of 1-2 μm and composite microspheres of chitosan coated cellulose with size of 1-3 μm were obtained through a two-step spray-assisted approach. The spray coagulating process must combine with a spray drying step to guarantee the formation of stable microspheres of cellulose. This approach exhibits the following two main virtues. First, the preparation was performed using aqueous solution of cellulose as precursor in the absence of organic solvent and surfactant; Second, neither crosslinking agent nor separated crosslinking process was required for formation of stable microspheres. Moreover, the spray drying step also provided us with the chance to encapsulate guests into the resultant cellulose microspheres. The potential application of the cellulose microspheres acting as drug delivery vector has been studied in two PBS (phosphate-buffered saline) solution with pH values at 4.0 and 7.4 to mimic the environments of stomach and intestine, respectively.
Keyword Cellulose microspheres
Coagulating bath
Drug delivery
Spray coagulating
Spray drying
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 2012CB722705
2012AA110407
21103096
ZR2010BM024
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
Official 2015 Collection
 
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