Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor

Arvidsson, Ann-Kristin, Wraith, Amanda, Jönsson-Rylander, Ann-Cathrine and Larhammar, Dan (1998) Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor. Regulatory Peptides, 75-76 39-43. doi:10.1016/S0167-0115(98)00051-2

Author Arvidsson, Ann-Kristin
Wraith, Amanda
Jönsson-Rylander, Ann-Cathrine
Larhammar, Dan
Title Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor
Journal name Regulatory Peptides   Check publisher's open access policy
ISSN 0167-0115
Publication date 1998-09-25
Sub-type Article (original research)
DOI 10.1016/S0167-0115(98)00051-2
Volume 75-76
Start page 39
End page 43
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Neuropeptide Y (NPY) belongs to a family of structurally related neuroendocrine peptides that bind to G protein-coupled receptors. Five different receptor subtypes have recently been cloned in mammals and we have found another three receptor genes in the zebrafish, called zYa, zYb, and zYc, that appear to be distinct subtypes as deduced from their widely different sequences. To elucidate the evolutionary relationships between the mammalian and zebrafish receptors, we have used the zebrafish probes to isolate genomic clones from another teleost fish, the Atlantic cod, Gadus morhua. We present here the sequence of the cod Yb gene, whose deduced protein sequence is equally identical to the zebrafish Yb (69%) and Yc proteins (66%). The two zebrafish receptors are 76% identical to each other, suggesting that they arose by gene duplication in the zebrafish lineage after divergence from the cod lineage. The five cloned mammalian NPY-family receptors and the three cloned zebrafish NPY receptors indicate that this is the largest receptor family among all peptide receptors that belong to the superfamily of G protein-coupled receptors.
Keyword Evolution
G protein-coupled receptor
7TM receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Wed, 18 Jun 2014, 21:30:55 EST by Amanda W. Kijas on behalf of UQ Centre for Clinical Research