Distinct melanoma types based on reflectance confocal microscopy

Pellacani, Giovanni, De Pace, Barbara, Reggiani, Camilla, Cesinaro, Anna Maria, Argenziano, Giuseppe, Zalaudek, Iris, Soyer, H. Peter and Longo, Caterina (2014) Distinct melanoma types based on reflectance confocal microscopy. Experimental Dermatology, 23 6: 414-418. doi:10.1111/exd.12417


Author Pellacani, Giovanni
De Pace, Barbara
Reggiani, Camilla
Cesinaro, Anna Maria
Argenziano, Giuseppe
Zalaudek, Iris
Soyer, H. Peter
Longo, Caterina
Title Distinct melanoma types based on reflectance confocal microscopy
Journal name Experimental Dermatology   Check publisher's open access policy
ISSN 1600-0625
0906-6705
Publication date 2014-06-01
Year available 2014
Sub-type Article (original research)
DOI 10.1111/exd.12417
Volume 23
Issue 6
Start page 414
End page 418
Total pages 5
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2015
Language eng
Formatted abstract
Distinct melanoma types exist in relation to patient characteristics, tumor morphology, histopathologic aspects and genetic background. A new diagnostic imaging tool, reflectance confocal microscopy (RCM), allows in vivo analysis of a given lesion with nearly histologic resolution while offering a dynamic view of the tissue in its ‘natural’ environment. The aim of this study was to analyse cell morphology of consecutive melanomas as they appear on RCM and to correlate morphology with tumor and patient characteristics. One hundred melanomas were visualized by RCM before excision. Clinical data, confocal features and histologic criteria were analysed. Four types of melanomas were identified as follows: (i) Melanomas with a predominantly dendritic cell population (‘dendritic-cell melanomas’) typically were thin by Breslow index; (ii) Melanomas typified by roundish melanocytes were smaller in size than dendritic cell MMs, but thicker by Breslow index, and predominantly occurred in patients with a high nevus count; (iii) Melanomas characterized by dermal nesting proliferation usually were thick by Breslow index at the time of diagnosis, although frequently smaller in size compared with the other types; and (iv) combined type melanomas may represent an evolution of dendritic cell and/or round cell types. Integration of confocal microscopy with clinical and histologic aspects may help in identifying and managing distinct tumors.
Keyword Confocal microscopy
Dermoscopy
Histopathology
Melanoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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