Endothelial cell-cell adhesion during zebrafish vascular development

Lagendijk, Anne Karine, Yap, Alpha S. and Hogan, Benjamin M. (2014) Endothelial cell-cell adhesion during zebrafish vascular development. Cell Adhesion and Migration, 8 2: 136-145. doi:10.4161/cam.28229

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Author Lagendijk, Anne Karine
Yap, Alpha S.
Hogan, Benjamin M.
Title Endothelial cell-cell adhesion during zebrafish vascular development
Journal name Cell Adhesion and Migration   Check publisher's open access policy
ISSN 1933-6918
Publication date 2014-01-01
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4161/cam.28229
Open Access Status Not Open Access
Volume 8
Issue 2
Start page 136
End page 145
Total pages 10
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Language eng
Subject 1307 Cell Biology
2804 Cellular and Molecular Neuroscience
Abstract The vertebrate vasculature is an essential organ network with major roles in health and disease. The establishment of balanced cell-cell adhesion in the endothelium is crucial for the functionality of the vascular system. Furthermore, the correct patterning and integration of vascular endothelial cell-cell adhesion drives the morphogenesis of new vessels, and is thought to couple physical forces with signaling outcomes during development. Here, we review insights into this process that have come from studies in zebrafish. First, we describe mutants in which endothelial adhesion is perturbed, second we describe recent progress using in vivo cell biological approaches that allow the visualization of endothelial cell-cell junctions. These studies underline the profound potential of this model system to dissect in great detail the function of both known and novel regulators of endothelial cell-cell adhesion.
Keyword Adherens junction
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 1083811
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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