Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy

Sime, Fekade Bruck, Roberts, Michael S., Warner, Morgyn S., Hahn, Uwe, Robertson, Thomas A., Yeend, Sue, Phay, Andy, Lehman, Sheila, Lipman, Jeffrey, Peake, Sandra L. and Roberts, Jason A. (2014) Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy. Antimicrobial Agents and Chemotherapy, 58 6: 3533-3537. doi:10.1128/AAC.02340-14

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Author Sime, Fekade Bruck
Roberts, Michael S.
Warner, Morgyn S.
Hahn, Uwe
Robertson, Thomas A.
Yeend, Sue
Phay, Andy
Lehman, Sheila
Lipman, Jeffrey
Peake, Sandra L.
Roberts, Jason A.
Title Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
1098-6596
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1128/AAC.02340-14
Open Access Status File (Publisher version)
Volume 58
Issue 6
Start page 3533
End page 3537
Total pages 5
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Subject 2736 Pharmacology (medical)
3004 Pharmacology
2725 Infectious Diseases
Abstract This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7±8.0 liters [mean±standard deviation]) and clearance (20.2±7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure.
Keyword Microbiology
Pharmacology & Pharmacy
Microbiology
Pharmacology & Pharmacy
MICROBIOLOGY
PHARMACOLOGY & PHARMACY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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