CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria

Lau, Lei Shong, Fernandez-Ruiz, Daniel, Mollard, Vanessa, Sturm, Angelika, Neller, Michelle A., Cozijnsen, Anton, Gregory, Julia L., Davey, Gayle M., Jones, Claerwen M., Lin, Yi-Hsuan, Haque, Ashraful, Engwerda, Christian R., Nie, Catherine Q., Hansen, Diana S., Murphy, Kenneth M., Papenfuss, Anthony T., Miles, John J., Burrows, Scott R., de Koning-Ward, Tania, McFadden, Geoffrey I., Carbone, Francis R., Crabb, Brendan S. and Heath, William R. (2014) CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria. PLoS Pathogens, 10 5: . doi:10.1371/journal.ppat.1004135


Author Lau, Lei Shong
Fernandez-Ruiz, Daniel
Mollard, Vanessa
Sturm, Angelika
Neller, Michelle A.
Cozijnsen, Anton
Gregory, Julia L.
Davey, Gayle M.
Jones, Claerwen M.
Lin, Yi-Hsuan
Haque, Ashraful
Engwerda, Christian R.
Nie, Catherine Q.
Hansen, Diana S.
Murphy, Kenneth M.
Papenfuss, Anthony T.
Miles, John J.
Burrows, Scott R.
de Koning-Ward, Tania
McFadden, Geoffrey I.
Carbone, Francis R.
Crabb, Brendan S.
Heath, William R.
Title CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria
Formatted title
CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria
Journal name PLoS Pathogens   Check publisher's open access policy
ISSN 1553-7374
1553-7366
Publication date 2014-05-01
Year available 2014
Sub-type Article (original research)
DOI 10.1371/journal.ppat.1004135
Open Access Status DOI
Volume 10
Issue 5
Total pages 16
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
To follow the fate of CD8+ T cells responsive to Plasmodium berghei ANKA (PbA) infection, we generated an MHC I-restricted TCR transgenic mouse line against this pathogen. T cells from this line, termed PbT-I T cells, were able to respond to blood-stage infection by PbA and two other rodent malaria species, P. yoelii XNL and P. chabaudi AS. These PbT-I T cells were also able to respond to sporozoites and to protect mice from liver-stage infection. Examination of the requirements for priming after intravenous administration of irradiated sporozoites, an effective vaccination approach, showed that the spleen rather than the liver was the main site of priming and that responses depended on CD8α+ dendritic cells. Importantly, sequential exposure to irradiated sporozoites followed two days later by blood-stage infection led to augmented PbT-I T cell expansion. These findings indicate that PbT-I T cells are a highly versatile tool for studying multiple stages and species of rodent malaria and suggest that cross-stage reactive CD8+ T cells may be utilized in liver-stage vaccine design to enable boosting by blood-stage infections.
Keyword Rodent malaria
CD8 T cells
Liver-stage immunity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article ID e1004135

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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