Morphometric stability of the corneal subbasal nerve plexus in healthy individuals: A 3-year longitudinal study using corneal confocal microscopy

Dehghani, Cirous, Pritchard, Nicola, Edwards, Katie, Vagenas, Dimitrios, Russell, Anthony W., Malik, Rayaz A. and Efron, Nathan (2014) Morphometric stability of the corneal subbasal nerve plexus in healthy individuals: A 3-year longitudinal study using corneal confocal microscopy. Investigative Ophthalmology and Visual Science, 55 5: 3195-3199. doi:10.1167/iovs.14-13959


Author Dehghani, Cirous
Pritchard, Nicola
Edwards, Katie
Vagenas, Dimitrios
Russell, Anthony W.
Malik, Rayaz A.
Efron, Nathan
Title Morphometric stability of the corneal subbasal nerve plexus in healthy individuals: A 3-year longitudinal study using corneal confocal microscopy
Journal name Investigative Ophthalmology and Visual Science   Check publisher's open access policy
ISSN 0146-0404
1552-5783
Publication date 2014-04-24
Year available 2014
Sub-type Article (original research)
DOI 10.1167/iovs.14-13959
Open Access Status DOI
Volume 55
Issue 5
Start page 3195
End page 3199
Total pages 5
Place of publication Rockville, MD United States
Publisher Association for Research in Vision and Ophthalmology Inc.
Language eng
Subject 2731 Ophthalmology
2809 Sensory Systems
2804 Cellular and Molecular Neuroscience
Abstract Purpose. We examined the age-dependent alterations and longitudinal course of subbasal nerve plexus (SNP) morphology in healthy individuals. Methods. Laser-scanning corneal confocal microscopy ocular screening, and health and metabolic assessment were performed on 64 healthy participants at baseline and at 12-month intervals for 3 years. At each annual visit, eight central corneal images of the SNP were selected and analyzed using a fully-automated analysis system to quantify corneal nerve fiber length (CNFL). Two linear mixed model approaches were fitted to examine the relationship between age and CNFL, and the longitudinal changes of CNFL over three years. Results. At baseline, mean age was 51.9 ± 14.7 years. The cohort was sex balanced (x2 - 0.56, P - 0.45). Age (t - 1.6, P - 0.12) and CNFL (t - -0.50, P - 0.62) did not differ between sexes. A total of 52 participants completed the 36-month visit and 49 participants completed all visits. Age had a significant effect on CNFL (F[1,33] - 5.67, P - 0.02) with a linear decrease of 0.05 mm/mm2 in CNFL per one year increase in age. No significant change in CNFL was observed over the 36-month period (F[155] - 0.69, P - 0.41). Conclusions. The CNFL showed a stable course over a 36-month period in healthy individuals, although there was a slight linear reduction in CNFL with age. The findings of this study have implications for understanding the time-course of the effect of pathology and surgical or therapeutic interventions on the morphology of the SNP, and serves to confirm the suitability of CNFL as a screening/monitoring marker for peripheral neuropathies.
Keyword Age
Corneal confocal microscopy
Natural history
Subbasal nerve plexus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 17 Jun 2014, 10:54:22 EST by System User on behalf of Medicine - Princess Alexandra Hospital