A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: An overview of individual participant data from 32 prospective cohorts from the Asia-Pacific Region

Huxley, Rachel R., Barzi, Federica, Woo, Jean, Giles, Graham, Lam, Tai Hing, Rahimi, Kazem, Konety, Suma, Ohkubo, Takayoshi, Jee, Sun Ha, Fang, Xianghua, Woodward, Mark and Asia Pacific Cohort Studies Collaboration (2014) A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: An overview of individual participant data from 32 prospective cohorts from the Asia-Pacific Region. BMC Cardiovascular Disorders, 14 61: . doi:10.1186/1471-2261-14-61


Author Huxley, Rachel R.
Barzi, Federica
Woo, Jean
Giles, Graham
Lam, Tai Hing
Rahimi, Kazem
Konety, Suma
Ohkubo, Takayoshi
Jee, Sun Ha
Fang, Xianghua
Woodward, Mark
Asia Pacific Cohort Studies Collaboration
Title A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: An overview of individual participant data from 32 prospective cohorts from the Asia-Pacific Region
Journal name BMC Cardiovascular Disorders   Check publisher's open access policy
ISSN 1471-2261
Publication date 2014-05-03
Year available 2014
Sub-type Article (original research)
DOI 10.1186/1471-2261-14-61
Open Access Status DOI
Volume 14
Issue 61
Total pages 10
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Background: Most of what is known regarding the epidemiology of mortality from heart failure (HF) comes from studies within Western populations with few data available from the Asia-Pacific region where the burden of heart failure is increasing.Methods: Individual level data from 543694 (85% Asian; 36% female) participants from 32 cohorts in the Asia Pacific Cohort Studies Collaboration were included in the analysis. Adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality from HF were estimated separately for Asians and non-Asians for a quintet of cardiovascular risk factors: systolic blood pressure, diabetes, body mass index, cigarette smoking and total cholesterol. All analyses were stratified by sex and study.Results: During 3,793,229 person years of follow-up there were 614 HF deaths (80% Asian). The positive associations between elevated blood pressure, obesity, and cigarette smoking were consistent for Asians and non-Asians. There was evidence to indicate that diabetes was a weaker risk factor for death from HF for Asians compared with non-Asians: HR 1.26 (95% CI: 0.74-2.13) versus 3.04 (95% CI 1.76-5.25) respectively; p for interaction = 0.022. Additional adjustment for covariates did not materially change the overall associations. There was no good evidence to indicate that total cholesterol was a risk factor for HF mortality in either population.Conclusions: Most traditional cardiovascular risk factors including elevated blood pressure, obesity and cigarette smoking appear to operate similarly to increase the risk of death from HF in Asians and non-Asians populations alike.
Keyword Epidemiology
Heart failure
Meta-analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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