Stripe-rearing changes multiple aspects of the structure of primary visual cortex

Hughes, Nicholas J., Hunt, Jonathan J., Cloherty, Shaun L., Ibbotson, Michael R., Sengpiel, Frank and Goodhill, Geoffrey J. (2014) Stripe-rearing changes multiple aspects of the structure of primary visual cortex. NeuroImage, 95 305-319. doi:10.1016/j.neuroimage.2014.03.031

Author Hughes, Nicholas J.
Hunt, Jonathan J.
Cloherty, Shaun L.
Ibbotson, Michael R.
Sengpiel, Frank
Goodhill, Geoffrey J.
Title Stripe-rearing changes multiple aspects of the structure of primary visual cortex
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2014-07-15
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2014.03.031
Open Access Status Not yet assessed
Volume 95
Start page 305
End page 319
Total pages 15
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Subject 2805 Cognitive Neuroscience
2808 Neurology
2700 Medicine
Abstract An important example of brain plasticity is the change in the structure of the orientation map in mammalian primary visual cortex in response to a visual environment consisting of stripes of one orientation. In principle there are many different ways in which the structure of a normal map could change to accommodate increased preference for one orientation. However, until now these changes have been characterised only by the relative sizes of the areas of primary visual cortex representing different orientations. Here we extend to the stripe-reared case a recently proposed Bayesian method for reconstructing orientation maps from intrinsic signal optical imaging data. We first formulated a suitable prior for the stripe-reared case, and developed an efficient method for maximising the marginal likelihood of the model in order to determine the optimal parameters. We then applied this to a set of orientation maps from normal and stripe-reared cats. This analysis revealed that several parameters of overall map structure, specifically the difference between wavelength, scaling and mean of the two vector components of maps, changed in response to stripe-rearing, which together give a more nuanced assessment of the effect of rearing condition on map structure than previous measures. Overall this work expands our understanding of the effects of the environment on brain structure.
Keyword Gaussian processes
Optical imaging
Orientation preference maps
Stripe rearing
Visual cortex
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID BB/J002089/1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Queensland Brain Institute Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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