BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla

Goa, Pål E., Koopmans, Peter J., Poser, Benedikt A., Barth, Markus and Norris, David G. (2014) BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla. Frontiers in Neuroscience, 8 49: 1-6. doi:10.3389/fnins.2014.00049

Author Goa, Pål E.
Koopmans, Peter J.
Poser, Benedikt A.
Barth, Markus
Norris, David G.
Title BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla
Journal name Frontiers in Neuroscience   Check publisher's open access policy
ISSN 1662-4548
Publication date 2014-03-13
Year available 2014
Sub-type Article (original research)
DOI 10.3389/fnins.2014.00049
Open Access Status DOI
Volume 8
Issue 49
Start page 1
End page 6
Total pages 6
Editor Nikolaus Weiskopf
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Formatted abstract
Object: To compare the BOLD fMRI signal characteristics at in the cortex and on the pial surface for a non-balanced steady-state free precession sequence (nb-SSFP) at 7 T.

Materials and Methods: A multi-echo nb-SSFP sequence was used for high resolution fMRI at 7 T. Two S1 (S+) echoes at different echo times were acquired together with an S2 (S) echo. The primary visual cortex (V1) was examined using a reversing checkerboard paradigm at an isotropic resolution of 0.75 mm, with 35 volumes acquired and a total scan time of 27 min.

Results: Significant activation was observed in all subjects for all three acquired echoes. For the S1 signal at the longer TE, the activation induced signal change was about 4% in the cortex and 10% at the cortical surface, while for S2 the corresponding values were 3 and 5%.

Conclusion: For both S1 and S2 data, the BOLD signal peaks at the pial surface. The large pial surface signal change in S2 may be caused by dynamic averaging around post-capillary vessels embedded within CSF. This is made possible by the long diffusion times of the pathways contributing to the S2 signal and the relatively high diffusion coefficient of CSF. The results indicate that S2-SSFP might not be a suited alternative to spin-echo for high-resolution fMRI at 7 T.
Keyword 7T
Steady-state free precession
Visual cortex
Blood oxygenation level-dependent (BOLD) functional MRI
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 13 Jun 2014, 02:23:22 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging