Tumour size as a predictor of axillary node metastases in patients with breast cancer

Laura S., Coombs N.J., Ung O. and Boyages J. (2006) Tumour size as a predictor of axillary node metastases in patients with breast cancer. ANZ Journal of Surgery, 76 11: 1002-1006. doi:10.1111/j.1445-2197.2006.03918.x

Author Laura S.
Coombs N.J.
Ung O.
Boyages J.
Title Tumour size as a predictor of axillary node metastases in patients with breast cancer
Journal name ANZ Journal of Surgery   Check publisher's open access policy
ISSN 1445-1433
Publication date 2006-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1111/j.1445-2197.2006.03918.x
Open Access Status Not yet assessed
Volume 76
Issue 11
Start page 1002
End page 1006
Total pages 5
Place of publication OXFORD
Language eng
Subject 2746 Surgery
Abstract Background: The ability to predict the behaviour of breast cancer from its dimensions allows the clinician to inform a woman about the absolute benefits of adjuvant therapies or further surgery to control her disease. Tumour size and grade are independent predictors of nodal disease. This study aims to generate a tool, using Australian data, allowing surgeons to calculate the probability of axillary lymph node involvement in a preoperative setting. Methods: The histological reports of patients with breast cancer treated in 1995 in New South Wales were examined and tumour size, grade and nodal status recorded. Univariate and multivariate analyses identified predictors of node positivity and, using linear regression analysis, a simple formula to predict nodal involvement was derived. Results: In a 6-month period, 754 women had non-metastatic, unifocal breast cancer treated with surgery and complete axillary dissection and 283 (37.5%) had positive nodes. Tumour size remained an independent predictor of node positivity and the probability (%), y, of nodal involvement may be predicted by the formula y = 1.5 × tumour size (mm) + 7, r = 0.939 and P = 0.001. Conclusion: This paper shows the need to assess the axilla in every patient because even patients with small tumours (0-5 mm) have the possibility of axillary involvement (7-14.5%). Use of this simple formula allows clinicians and patients to make informed decisions about the possible need for a full axillary dissection to reduce the chance of understaging and potentially undertreating a woman's breast cancer.
Keyword Axilla
Breast neoplasm
Lymph node excision
Neoplasm metastasis
Projection and prediction
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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