Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis

Schlapbach, Luregn J., Aebi, Christoph, Fisch, Urs, Ammann, Roland A., Otth, Margrith, Bigler, Susanne, Nelle, Mathias, Berger, Steffen and Kessler, Ulf (2008) Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis. Pediatric Research, 64 5: 562-566. doi:10.1203/PDR.0b013e3181841335


Author Schlapbach, Luregn J.
Aebi, Christoph
Fisch, Urs
Ammann, Roland A.
Otth, Margrith
Bigler, Susanne
Nelle, Mathias
Berger, Steffen
Kessler, Ulf
Title Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
1530-0447
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1203/PDR.0b013e3181841335
Volume 64
Issue 5
Start page 562
End page 566
Total pages 5
Place of publication New York, NY, United States
Publisher Nature Publishing
Language eng
Abstract Necrotising enterocolitis (NEC) causes significant morbidity and mortality in premature infants. The role of innate immunity in the pathogenesis of NEC remains unclear. Mannose-binding lectin (MBL) recognizes microorganisms and activates the complement system via MBL-associated serine protease-2 (MASP-2). The aim of this study was to investigate whether MBL and MASP-2 are associated with NEC. This observational case-control study included 32 infants with radiologically confirmed NEC and 64 controls. MBL and MASP-2 were measured in cord blood using ELISA. Multivariate logistic regression was performed. Of the 32 NEC cases (median gestational age, 30.5 wk), 13 (41%) were operated and 5 (16%) died. MASP-2 cord blood concentration ranged from undetectable (< 10 ng/mL) to 277 ng/mL. Eighteen of 32 (56%) NEC cases had higher MASP-2 levels (>30 ng/mL) compared with 22 of 64 (34%) controls (univariate OR 2.46; 95% CI 1.03-5.85; p = 0.043). Higher cord blood MASP-2 levels were significantly associated with an increased risk of NEC in multivariate analysis (OR 3.00; 95% CI 1.17-7.93; p = 0.027). MBL levels were not associated with NEC (p = 0.64). In conclusion, infants later developing NEC had significantly higher MASP-2 cord blood levels compared with controls. Higher MASP-2 may favor complement-mediated inflammation and could thereby predispose to NEC. Copyright
Keyword Pediatrics
Pediatrics
PEDIATRICS
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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