Distinct relationships of intramuscular and subcutaneous fat with cortical bone: Findings from a cross-sectional study of young adult males and females

Deere, K., Sayers, A., Viljakainen, H. T., Lawlor, D. A., Sattar, N., Kemp, J. P., Fraser, W. D. and Tobias, J. H. (2013) Distinct relationships of intramuscular and subcutaneous fat with cortical bone: Findings from a cross-sectional study of young adult males and females. Journal of Clinical Endocrinology and Metabolism, 98 6: E1041-E1049. doi:10.1210/jc.2013-1272


Author Deere, K.
Sayers, A.
Viljakainen, H. T.
Lawlor, D. A.
Sattar, N.
Kemp, J. P.
Fraser, W. D.
Tobias, J. H.
Title Distinct relationships of intramuscular and subcutaneous fat with cortical bone: Findings from a cross-sectional study of young adult males and females
Journal name Journal of Clinical Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0021-972X
1945-7197
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1210/jc.2013-1272
Open Access Status DOI
Volume 98
Issue 6
Start page E1041
End page E1049
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central Ltd.
Language eng
Subject 1303 Specialist Studies in Education
1308 Clinical Biochemistry
1310 Endocrinology
2704 Biochemistry, medical
2712 Endocrinology, Diabetes and Metabolism
Abstract Context: Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development. Objective: The aim of the study was to evaluate associations between im fat, as reflected by muscle density as measured by peripheral quantitative computed tomography, and cortical bone parameters in young adults. Design/Setting/Participants: We conducted a cross-sectional analysis of 1703 males and 2243 females aged 17.8 years from the Avon Longitudinal Study of Parents and Children. Outcome Measures: We measured cortical bone parameters from midtibial peripheral quantitative computed tomography scans. Results: Muscle density (inversely related to im fat) was inversely associated with periosteal circumference (PC) (beta = -0.07 [95% confidence interval (CI), -0.1, -0.04]), cortical bone mineral density (BMD C) (beta = -0.21 [95% CI, -0.26, -0.17]), and cortical thickness (CT) (beta = -0.37[95% CI, -0.42, -0.33]) (males and females combined, adjusted for age, height, gender, and muscle cross-sectional area). In contrast, sc fat area was positively associated with PC (beta = 0.10 [95% CI, 0.07, 0.12]), but no association was seen with BMDC or CT. To examine the role of candidate intermediary metabolic pathways, analyses were repeated after adjustment for insulin, C-reactive protein, and β-C-telopeptides of type I collagen. Whereas similar associations were observed after adjustment for insulin and C-reactive protein, the association between muscle density and BMDC was partially attenuated by adjustment for β-C-telopeptides of type I collagen (beta = -0.14 [95% CI, -0.20, -0.08]). Conclusion: Although im and sc fat were both positively associated with cortical bone mass, the nature of these relationships differed in that im fat was predominantly associated with CT and BMDC, whereas sc fat was mainly associated with PC. These relationships were largely independent of candidate metabolic pathways, such as altered bone resorption, insulin resistance, or inflammation. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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Created: Wed, 11 Jun 2014, 22:02:03 EST by Kylie Hengst on behalf of UQ Diamantina Institute