Body stature growth trajectories during childhood and the development of myopia

Northstone, Kate, Guggenheim, Jeremy A., Howe, Laura D., Tilling, Kate, Paternoster, Lavinia, Kemp, John P., McMahon, George and Williams, Cathy (2013) Body stature growth trajectories during childhood and the development of myopia. Ophthalmology, 120 5: 1064-1073. doi:10.1016/j.ophtha.2012.11.004

Author Northstone, Kate
Guggenheim, Jeremy A.
Howe, Laura D.
Tilling, Kate
Paternoster, Lavinia
Kemp, John P.
McMahon, George
Williams, Cathy
Title Body stature growth trajectories during childhood and the development of myopia
Journal name Ophthalmology   Check publisher's open access policy
ISSN 0161-6420
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.ophtha.2012.11.004
Open Access Status DOI
Volume 120
Issue 5
Start page 1064
End page 1073
Total pages 10
Place of publication Philadelphia, PA United States
Publisher Elsevier Inc.
Language eng
Subject 2731 Ophthalmology
Abstract Purpose: Stature at a particular age can be considered the cumulative result of growth during a number of preceding growth trajectory periods. We investigated whether height and weight growth trajectories from birth to age 10 years were related to refractive error at ages 11 and 15 years, and eye size at age 15 years. Design: Prospective analysis in a birth cohort. Participants: Children participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) U.K. birth cohort (minimum N = 2676). Methods: Growth trajectories between birth and 10 years were modeled from a series of height and weight measurements (N = 6815). Refractive error was assessed by noncycloplegic autorefraction at ages 11 and 15 years (minimum N = 4737). Axial length (AXL) and radius of corneal curvature were measured with an IOLMaster (Carl Zeiss Meditec, Welwyn Garden City, U.K.) at age 15 years (minimum N = 2676). Growth trajectories and an allelic score for 180 genetic variants associated with adult height were tested for association with refractive error and eye size. Main Outcome Measures: Noncycloplegic autorefraction at ages 11 and 15 years, and AXL and corneal curvature at age 15 years. Results: Height growth trajectory during the linear phase between 2.5 and 10 years was negatively associated with refractive error at 11 and 15 years (P<0.001), but explained <0.5% of intersubject variation. Height and weight growth trajectories, especially shortly after birth, were positively associated with AXL and corneal curvature (P<0.001), predicting 1% to 5% of trait variation. Height growth after 2.5 years was not associated with corneal curvature, whereas the association with AXL continued up to 10 years. The height allelic score was associated with corneal curvature (P = 0.03) but not with refractive error or AXL. Conclusions: Up to the age of 10 years, shared growth mechanisms contribute to scaling of eye and body size but minimally to the development of myopia.
Keyword Ophthalmology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID SCIAD 053
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
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Created: Wed, 11 Jun 2014, 21:39:16 EST by Kylie Hengst on behalf of UQ Diamantina Institute