H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients

Schlapbach, L. J., Aebi, C., Hansen, A. G., Hirt, A., Jensenius, J. C. and Ammann, R. A. (2009) H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients. Clinical and Experimental Immunology, 157 1: 83-89. doi:10.1111/j.1365-2249.2009.03957.x


Author Schlapbach, L. J.
Aebi, C.
Hansen, A. G.
Hirt, A.
Jensenius, J. C.
Ammann, R. A.
Title H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients
Journal name Clinical and Experimental Immunology   Check publisher's open access policy
ISSN 0009-9104
1365-2249
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.1111/j.1365-2249.2009.03957.x
Volume 157
Issue 1
Start page 83
End page 89
Total pages 7
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract H-ficolin (Hakata antigen, ficolin-3) activates the lectin pathway of complement similar to mannose-binding lectin. However, its impact on susceptibility to infection is currently unknown. This study investigated whether the serum concentration of H-ficolin at diagnosis is associated with fever and neutropenia (FN) in paediatric cancer patients. H-ficolin was measured by time-resolved immunofluorometric assay in serum taken at cancer diagnosis from 94 children treated with chemotherapy. The association of FN episodes with H-ficolin serum concentration was analysed by multivariate Poisson regression. Median concentration of H-ficolin in serum was 26 mg/l (range 6-83). Seven (7%) children had low H-ficolin (< 14 mg/l). During a cumulative chemotherapy exposure time of 82 years, 177 FN episodes were recorded, 35 (20%) of them with bacteraemia. Children with low H-ficolin had a significantly increased risk to develop FN [relative risk (RR) 2·24; 95% confidence interval (CI) 1·38-3·65; P = 0·004], resulting in prolonged duration of hospitalization and of intravenous anti-microbial therapy. Bacteraemia occurred more frequently in children with low H-ficolin (RR 2·82; CI 1·02-7·76; P = 0·045). In conclusion, low concentration of H-ficolin was associated with an increased risk of FN, particularly FN with bacteraemia, in children treated with chemotherapy for cancer. Low H-ficolin thus represents a novel risk factor for chemotherapy-related infections.
Keyword Bacteraemia
Cancer
Fever and neutropenia
H-ficolin
Innate immunity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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