Mannose-binding lectin cord blood levels and respiratory symptoms during infancy: A prospective birth cohort study

Schlapbach, Luregn Jan, Latzin, Philipp, Regamey, Nicolas, Kuehni, Claudia E., Zwahlen, Marcel, Casaulta, Carmen, Aebi, Christoph and Frey, Urs (2009) Mannose-binding lectin cord blood levels and respiratory symptoms during infancy: A prospective birth cohort study. Pediatric Allergy and Immunology, 20 3: 219-226. doi:10.1111/j.1399-3038.2008.00782.x


Author Schlapbach, Luregn Jan
Latzin, Philipp
Regamey, Nicolas
Kuehni, Claudia E.
Zwahlen, Marcel
Casaulta, Carmen
Aebi, Christoph
Frey, Urs
Title Mannose-binding lectin cord blood levels and respiratory symptoms during infancy: A prospective birth cohort study
Journal name Pediatric Allergy and Immunology   Check publisher's open access policy
ISSN 0905-6157
1399-3038
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1399-3038.2008.00782.x
Volume 20
Issue 3
Start page 219
End page 226
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract Respiratory infections cause considerable morbidity during infancy. The impact of innate immunity mechanisms, such as mannose-binding lectin (MBL), on respiratory symptoms remains unclear. The aims of this study were to investigate whether cord blood MBL levels are associated with respiratory symptoms during infancy and to determine the relative contribution of MBL when compared with known risk factors. This is a prospective birth cohort study including 185 healthy term infants. MBL was measured in cord blood and categorized into tertiles. Frequency and severity of respiratory symptoms were assessed weekly until age one. Association with MBL levels was analysed using multivariable random effects Poisson regression. We observed a trend towards an increased incidence rate of severe respiratory symptoms in infants in the low MBL tertile when compared with infants in the middle MBL tertile [incidence rate ratio (IRR) = 1.59; 95% confidence interval (CI): 0.95-2.66; p = 0.076]. Surprisingly, infants in the high MBL tertile suffered significantly more from severe and total respiratory symptoms than infants in the middle MBL tertile (IRR = 1.97; 95% CI: 1.20-3.25; p = 0.008). This association was pronounced in infants of parents with asthma (IRR = 3.64; 95% CI: 1.47-9.02; p = 0.005). The relative risk associated with high MBL was similar to the risk associated with well-known risk factors such as maternal smoking or childcare. In conclusion the association between low MBL levels and increased susceptibility to common respiratory infections during infancy was weaker than that previously reported. Instead, high cord blood MBL levels may represent a so far unrecognized risk factor for respiratory morbidity in infants of asthmatic parents.
Keyword Asthma
Infant
Innate immunity
Mannose-binding lectin
Respiratory infection
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 3200-B0-112099
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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