Fatal pulmonary embolism in a premature neonate after twin-to-twin transfusion syndrome

Schlapbach, Luregn Jan, Riedel, Thomas, Genitsch, Vera, Nelle, Mathias and McDougall, Felicity Jane (2010) Fatal pulmonary embolism in a premature neonate after twin-to-twin transfusion syndrome. Pediatrics, 126 2: E483-E487. doi:10.1542/peds.2009-3490


Author Schlapbach, Luregn Jan
Riedel, Thomas
Genitsch, Vera
Nelle, Mathias
McDougall, Felicity Jane
Title Fatal pulmonary embolism in a premature neonate after twin-to-twin transfusion syndrome
Journal name Pediatrics   Check publisher's open access policy
ISSN 0031-4005
1098-4275
Publication date 2010-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1542/peds.2009-3490
Volume 126
Issue 2
Start page E483
End page E487
Total pages 5
Place of publication Elk Grove Village, IL United States
Publisher American Academy of Pediatrics
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
Abstract Thrombotic events are being increasingly recognized during the neonatal period. An infant girl was born at 29 weeks' gestation after a pregnancy complicated by twin-to-twin transfusion syndrome. After an initial uncomplicated clinical course, her oxygen requirement increased, which was interpreted as an early sign of bronchopulmonary dysplasia. At 3 weeks of age, she suddenly collapsed and died of severe pulmonary hypertension. At autopsy, multiple pulmonary artery emboli and several older renal vein thromboses were found. Results of genetic analyses of the infant and her family were negative for thrombophilia. Although embolism represents a frequent emergency in adults, fatal pulmonary embolism has never, to our knowledge, been described for premature infants. This case suggests that thrombotic events are underdiagnosed and that additional studies are needed to define infants at risk and optimal treatment strategies. Copyright
Keyword Premature infant
Pulmonary embolism
Renal vein thrombosis
Twin-twin transfusion
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 11 Jun 2014, 20:59:03 EST by System User on behalf of Paediatrics & Child Health - Mater Hospital