Impact of chorioamnionitis and preeclampsia on neurodevelopmental outcome in preterm infants below 32 weeks gestational age

Schlapbach, Luregn J., Ersch, Jörg, Adams, Mark, Bernet, Vera, Bucher, Hans Ulrich and Latal, Beatrice (2010) Impact of chorioamnionitis and preeclampsia on neurodevelopmental outcome in preterm infants below 32 weeks gestational age. Acta Paediatrica, International Journal of Paediatrics, 99 10: 1504-1509. doi:10.1111/j.1651-2227.2010.01861.x


Author Schlapbach, Luregn J.
Ersch, Jörg
Adams, Mark
Bernet, Vera
Bucher, Hans Ulrich
Latal, Beatrice
Title Impact of chorioamnionitis and preeclampsia on neurodevelopmental outcome in preterm infants below 32 weeks gestational age
Journal name Acta Paediatrica, International Journal of Paediatrics   Check publisher's open access policy
ISSN 0803-5253
1651-2227
Publication date 2010-01-01
Sub-type Article (original research)
DOI 10.1111/j.1651-2227.2010.01861.x
Volume 99
Issue 10
Start page 1504
End page 1509
Total pages 6
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Aim: Intrauterine conditions may interfere with foetal brain development. We compared the neurodevelopmental outcome between infants <32 weeks gestational age after maternal preeclampsia or chorioamnionitis and controls.

Methods: Case-control study on infants with maternal preeclampsia, chorioamnionitis and controls (each n = 33) matched for gestational age. Neurodevelopment at 2 years was assessed with the Bayley Scales of Infant Development II.

Results: A total of 99 infants were included with a median gestational age of 29 weeks (range 25-32). Median mental developmental index (MDI) was 96 in the control, 90 in the chorioamnionitis and 86 in the preeclampsia group. Preeclampsia infants had a lower MDI compared with the control group (univariate p = 0.021, multivariate p = 0.183) and with the chorioamnionitis group (univariate p = 0.242; multivariate p = 0.027). Median psychomotor index was 80.5 in the control, 80 in the preeclampsia and 85 in the chorioamnionitis group and was not different between these three groups (p > 0.05). Chorioamnionitis or preeclampsia exposure was not associated with major neurodevelopmental impairments (cerebral palsy, MDI<70, PDI<70).

Conclusion: The results of this preliminary study suggest that preeclampsia and chorioamnionitis play a relatively minor role among risk factors for adverse neurodevelopment outcome. Postnatal factors such as ventilation and bronchopulmonary dysplasia may have a greater impact on neurodevelopmental outcome. 
Keyword Cerebral palsy
Chorioamnionitis
Neurodevelopment
Preeclampsia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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